ISSN 2072-9294
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ISSN 2072-9308
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The elaboration of the works

During the elaboration of the works rule the follow norms:

The manuscript (including tables and references) must be written in Times New Roman 12 cpi character and in letter size paper sheets, with left and right margin, superior and inferior 2.5 cm, double space. Values must come in measure tiff, with a minimum resolution of 300 dpi. Tables and figures must come in a separate document.

Puting together the full article.

It must be organized as follow:


Authors: There are no graduations or titles, in case that the authors wish to appear with both last names they must use a hyphen between them. The full name and address of the center or institution where each author works. The P.O. Box, phone number, fax and E-mail of each one of the authors. This page will also contain the correspondence of the designed author.
Title: No more than 250 characters. It must be concise, but informative. It can be written in Spanish, Portuguese or English.

Abstract: A maximum extension of 250 words. The purpose of the study or investigation will be indicated, the more important results and the principal conclusions. Emphasize in the new and important aspects of the study or the observations.

Key words: There will be a minimum of 3 and a maximum of 10 key words used in the index medicus (Medical Subject Heading). Available in <http://www.ncbi.nlm.>

The text of the work must be divided in the follow epigraphs: Introduction, Materials and Methods, Results, Discussion and Thankfulness. Specially complex articles can include additional explanations in some sections to help the comprehension of its content.

Introduction: It must determinate the purpose of the study, resume the logic foundation of the study or observation. It has to mention the strictly and pertinent references, without making an extensive revision of the subject. Do not include data or conclusions of the work you are giving to know, detail what new advances were obtained though the investigation.  In the final paragraph you must expose the objectives of the work, in a clear and concrete way.

Materials and Methods: The work has to describe clearly the way the experiments or subjects observed or that participated in the experiments were selected (patients, laboratory animals, witness included, biological material). It must identify the methods, apparatus (name and address of the manufacturer in parenthesis) and the procedures with enough details so that other investigators could reproduce the results easily.

References of the accredited methods must be given, including those of statistic inclination, describing the new methods substantially modified, expressing the reasons of why they were used and evaluating its limitations. All the used medicines and chemical products have to be identified, without forgetting the generic names, doses and way of administration.

Ethic: For the description of the experiments related with human beings, it has to be indicate that the followed procedures are those described in the ethic norms of the responsible committee of human experimentation (institutional or regional) and it has to be consistent with the Helsinki Declaration of 1975, revised in 1983.

Sometimes the use of materials like detailed descriptions of photographs of individual patients, it could be the whole body or a part of it (included the physiognomical strokes) can reveal the patient`s identity, sometimes even indirectly, through a combination of data apparently innocuous. Patients (and their relatives) have the right to preserve their anonymity in the published clinic documentation. Details that can identify the patients must be avoided, but if they are essential for the scientific purposes. To cover the eyes of the patients in the photographs can be an insufficient protection to keep the anonymity.
The presentation of reports about experiments with animals, indicate that the directory for the investigation councils institutional or national, or about any national law for protection or use of laboratory animals were followed.

Statistics: The statistics methods with sufficient details must be described. You must quantify the results and present them with appropriate error or incertitude indicators of measure (for ex., confidence stretch). You must not accept just the proofs about the compotation of the statistic hypothesis, like the use of p values, that don’t transmit important quantitative information.
The election of the experimentation subjects must be analyzed. Give details about the chance process. Describe the used methods to masquerade the observations (blind method), indicating the obtained results. You have to give a report about the complications of the treatment. The number of observations must be specified. You have to mention the losses of the subjects observed (for ex., the persons that leave a clinic test). If it is possible, the references about the study`s design and statistic methods will belong to actual works (indicating the number of the pages), instead of the articles where they were described the first time. Any used computer program must be specified.    
The general descriptions about the used methods must appear in the methods section. When the data abstract is made in the results section, the statistic methods for its analysis must be specified. For the explanation of the central theme of the article and the evaluation of the data you are supported by use the minimum number of tables and figures. Use graphics instead of too many tables; do not duplicate the data in the graphics and the tables. Avoid the use of no technical terms like "at random" (that entrails the use of a chance method), "normal", "significant", "correlation" and "sample". Define the terms, abbreviations and most of the statistic symbols.

Results: They must offer a concise description about the new information discovery, with a minimum of personal judgment.  Do not repeat the text in all the data contained in the tables and illustrations, the results must be presented following a logic sequence, detach or resume only the most important observations. They must be presented in a logic sequence with the help of tables and figures, unnecessary repetitions of the results expressed in figures and tables must be avoided and only rebound the more relevant data.

Figures: They must be clearly marked with high contrast; the enlargement in black and white, bright paper in case of presenting slides, ciphers must be consecutive with Arabic numbers. Scales are indicated by a line or bar in the image, and it is included in the title if necessary (for ex., bar = 1 mm, etc.) and graphics must fit one column (8 cm) of width or the total of the page (16.5 cm) and it must be less than the full page so the title or legend can be included.  Letters and numbers of the figures have to be legible before the reduction of size or the impression. Illustrations in color can only be accepted if the authors accept an extra money charge. Besides, a color photograph is published in the title-page of each remembrance number, and the authors are invited to present for consideration of the journal the illustrations with the title of their manuscripts to be in the cover.

Tables: They must be complementary and not duplicate the text. They must be numerated with Roman numbers. A title and a short description may appear in the top of each table (identified with the letters a, b, c, etc.), without explanations or notes at the feet of the page.

Discussion: It must emphasize the new and most important aspects of the study and in the conclusions resulting of it. Do not repeat with details the data or other information already presented in the introductory or results sections. You must explain the meaning of the results and their limitations, including their consequences for the future investigation that could stimulate other authors to solve it. You must make a relation of the observations with the ones of other pertinent studies. The nexus of the conclusions with the study objectives must be established but abstain of making general affirmations and of making conclusions that are not completely supported buy the data. Do not claim any kind of origin and do not mention any unfinished work. You must propose any new hypothesis when there is any justification for it, but identify them clearly. Recommendations can be included if they are considered appropriate.

Thankfulness: In one or several statements you can  specify the following: a) the collaboration that must be recognized but do not justify the recognition as an author, as the general support of the department´s chief; b) the recognition for the technical help; c) the thankfulness for the material and economic support, specifying the inclination of it.

People that collaborated intellectually in the article but whose participation do not justify the recognition as an author, can be cited by their names, indicating the functions or the kind of collaboration; for example, “scientific advising”, “critic revision of the study proposition”, “data recollection” or “participation in the clinic test”. This people have to give the permission to be named. Authors are responsible for obtaining the written authorization of the named people in the thankfulness section, because lectors can deduce they support the data and conclusions.

The recognition for the technical help will figure in a separated paragraph of the testimonies of thankfulness for other contributions.
In the first page has to be indicated the economical sources for the study, if there is any.

Interest Conflict: Authors also have to indicate any economic relation that may exist that could represent an interest conflict in relation with the work printed in this journal. In the case of patronized studies, the authors have to indicate if they had full access to the data and they take responsibility for the integrity and the exactitude in it´s analysis

Literature cited: Only those that appear in the text must have a reference. Not published works, must be cited but if they have an acceptation for their publication. Those works must be cited as “in press”, in that case, a letter of acceptation must be given by the journal. Not published data must be cited in the text as “not published observations”, in which case a letter with permission from the author must be presented. In the text the bibliographic references of the authors must be mentioned in lower-case followed by the year, in chronologic order.
The titles of the journals must be short in agreement with the list of Journals Indexed and Index Medicus. Available in: <>.
The citations must be checked over the original articles and will be ordered by the Vancouver rules (1997, revised edition of October 2003), available in:, and the Spanish version in:
The follow examples are some used frequently.


In the text, use the last name of the author and the year:

  • González (1910) or (González 1910).

With two authors, the way is:

  • (Lutz & Neiva 1912) or Lutz & Neiva (1912)

When there are more than two authors, only the first one is mentioned:

  • Lutz et al (1910) or (Lutz et al 1910).


  1. Articles in journals.

Number the first six authors followed by et al. (Note: NLM now number all the authors).

  • Halpern SD, Ubel PA, Caplan AL. Solid-organ transplantation in HIV-infected patients. N Engl J Med. 2002 Jul 25;347(4):284-7.

As an option, if the journal has a continuous pagination (as most part of the medical journals does) the month and the number of the sample can be omitted.

  • Halpern SD, Ubel PA, Caplan AL. Solid-organ transplantation in HIV-infected patients. N Engl J Med. 2002;347:284-7.

More than six authors:

  • Rose ME, Huerbin MB, Melick J, Marion DW, Palmer AM, Schiding JK, et al. Regulation of interstitial excitatory amino acid concentrations after cortical contusion injury. Brain Res. 2002;935(1-2):40-6.
  1. Organization as an author.
  • Diabetes Prevention Program Research Group. Hypertension, insulin, and proinsulin in participants with impaired glucose tolerance. Hypertension. 2002;40(5):679-86.
  1. Personal authors and organizations as authors. (this example is not a NISO standard)
  • Vallancien G, Emberton M, Harving N, van Moorselaar RJ; Alf-One Study Group. Sexual dysfunction in 1,274 European men suffering from lower urinary tract symptoms. J Urol. 2003;169(6):2257-61.
  1. When the author is not given.
  • 21st century heart solution may have a sting in the tail. BMJ. 2002;325(7357):184.
  1. Articles in a language different to the English.

(Note: The NLM translate the title to the English, include the translation between clasps, and add an abbreviation given to the language).

  • Ellingsen AE, Wilhelmsen I. Sykdomsangst blant medisin- og jusstudenter. Tidsskr Nor Laegeforen. 2002;122(8):785-7.
  1. Exemplar with supplement.
  • Geraud G, Spierings EL, Keywood C. Tolerability and safety of frovatriptan with short- and long-term use for treatment of migraine and in comparison with sumatriptan. Headache. 2002;42 Suppl 2:S93-9.
  1. Published number with suplement.
  • Glauser TA. Integrating clinical trial data into clinical practice. Neurology. 2002;58(12 Suppl 7):S6-12.
  1. Part of an exemplar.
  • Abend SM, Kulish N. The psychoanalytic method from an epistemological viewpoint. Int J Psychoanal. 2002;83(Pt 2):491-5.
  1. Part of a published number.
  • Ahrar K, Madoff DC, Gupta S, Wallace MJ, Price RE, Wright KC. Development of a large animal model for lung tumors. J Vasc Interv Radiol. 2002;13(9 Pt 1):923-8.
  1. Number without exemplar.
  • Banit DM, Kaufer H, Hartford JM. Intraoperative frozen section analysis in revision total joint arthroplasty. Clin Orthop. 2002;(401):230-8.
  1. Without number and exemplar.
  • Outreach: bringing HIV-positive individuals into care. HRSA Careaction. 2002 Jun:1-6.
  1. Pagination in roman numbers.
  • Chadwick R, Schuklenk U. The politics of ethical consensus finding. Bioethics. 2002;16(2):iii-v.
  1. Indicating the kind of article when necessary.
  • Tor M, Turker H. International approaches to the prescription of long-term oxygen therapy [letter]. Eur Respir J. 2002;20(1):242.
  • Lofwall MR, Strain EC, Brooner RK, Kindbom KA, Bigelow GE. Characteristics of older methadone maintenance (MM) patients [abstract]. Drug Alcohol Depend. 2002;66 Suppl 1:S105.
  1. Article containing a retractation.
  • Feifel D, Moutier CY, Perry W. Safety and tolerability of a rapidly escalating dose-loading regimen for risperidone. J Clin Psychiatry. 2002;63(2):169. Retractado de: Feifel D, Moutier CY, Perry W. J Clin Psychiatry. 2000;61(12):909-11.
  1. Retracted article.
  • Feifel D, Moutier CY, Perry W. Safety and tolerability of a rapidly escalating dose-loading regimen for risperidone. J Clin Psychiatry. 2000;61(12):909-11. Retractado en: Feifel D, Moutier CY, Perry W. J Clin Psychiatry. 2002;63(2):169.
  1. Article published again with corrections.
  • Mansharamani M, Chilton BS. The reproductive importance of P-type ATPases. Mol Cell Endocrinol. 2002;188(1-2):22-5. Corrected and republished from: Mol Cell Endocrinol. 2001;183(1-2):123-6.
  1. Article with published erratum.
  • Malinowski JM, Bolesta S. Rosiglitazone in the treatment of type 2 diabetes mellitus: a critical review. Clin Ther. 2000;22(10):1151-68; discussion 1149-50. Erratum in: Clin Ther 2001;23(2):309.
  1. Article electronicaly published preceding the pressed version.
  • Yu WM, Hawley TS, Hawley RG, Qu CK. Immortalization of yolk sac-derived precursor cells. Blood. 2002 Nov 15;100(10):3828-31. Epub 2002 Jul 5.


  1. Personal author(s).
  • Murray PR, Rosenthal KS, Kobayashi GS, Pfaller MA. Medical microbiology. 4th ed. St. Louis: Mosby; 2002.
  1. Editor(s), compilator(s) as author(s).
  • Gilstrap LC 3rd, Cunningham FG, VanDorsten JP, editors. Operative obstetrics. 2nd ed. New York: McGraw-Hill; 2002.
  1. Author(s) and editor(s).
  • Breedlove GK, Schorfheide AM. Adolescent pregnancy. 2nd ed. Wieczorek RR, editor. White Plains (NY): March of Dimes Education Services; 2001.
  1. Organization(s) as author(s).
  • Royal Adelaide Hospital; University of Adelaide, Department of Clinical Nursing. Compendium of nursing research and practice development, 1999-2000. Adelaide (Australia): Adelaide University; 2001.
  1. Chapter from a book.
  • Meltzer PS, Kallioniemi A, Trent JM. Chromosome alterations in human solid tumours. En: Vogelstein B, Kinzler KW, editors. The genetic basis of human cancer. New York: McGraw-Hill; 2002. p. 93-113.
  1. Memories from a congress.
  • Harnden P, Joffe JK, Jones WG, editors. Germ cell tumours V. Proceedings of the 5th Germ Cell Tumour Conference; 2001 Sep 13-15; Leeds, UK. New York: Springer; 2002.
  1. Article from a congress.
  • Christensen S, Oppacher F. An analysis of Koza’s computational effort statistic for genetic programming. In: Foster JA, Lutton E, Miller J, Ryan C, Tettamanzi AG, editors. Genetic programming. EuroGP 2002: Proceedings of the 5th European Conference on Genetic Programming; 2002 Apr 3-5; Kinsdale, Ireland. Berlin: Springer; 2002. p. 182-91.
  1. Scientific or technical report.

Made by a financial/patronize agency:

  • Yen GG (Oklahoma State University, School of Electrical and Computer Engineering, Stillwater, OK). Health monitoring on vibration signatures. Final report. Arlington (VA): Air Force Office of Scientific Research (US), Air Force Research Laboratory; 2002 Feb. Report No.: AFRLSRBLTR020123. Contract No.: F496209810049.

Made by a performer agency:

  • Russell ML, Goth-Goldstein R, Apte MG, Fisk WJ. Method for measuring the size distribution of airborne Rhinovirus. Berkeley (CA): Lawrence Berkeley National Laboratory, Environmental Energy Technologies Division; 2002 Jan. Report No.: LBNL49574. Contract No.: DEAC0376SF00098. Sponsored by the Department of Energy.
  1. Dissertation.
  • Borkowski MM. Infant sleep and feeding: a telephone survey of Hispanic Americans [dissertation]. Mount Pleasant (MI): Central Michigan University; 2002.
  1. Patent.
  • Pagedas AC, inventor; Ancel Surgical R&D Inc., assignee. Flexible endoscopic grasping and cutting device and positioning tool assembly. United States patent US 20020103498. 2002 Aug 1.

Other published material.

  1. Newspaper article.
  • Tynan T. Medical improvements lower homicide rate: study sees drop in assault rate. The Washington Post. 2002 Aug 12;Sect. A:2 (col. 4).
  1. Audiovisual Material.
  • Chason KW, Sallustio S. Hospital preparedness for bioterrorism [videocassette]. Secaucus (NJ): Network for Continuing Medical Education; 2002.
  1. Legal Material.

Published Law.

  • Veterans Hearing Loss Compensation Act of 2002, Pub. L. No. 107-9, 115 Stat. 11 (May 24, 2001).

Project of a law not promulgated.

  • Healthy Children Learn Act, S. 1012, 107th Cong., 1st Sess. (2001).

Federal code or regulation.

  • Cardiopulmonary Bypass Intracardiac Suction Control, 21 C.F.R. Sect. 870.4430 (2002).


  • Arsenic in Drinking Water: An Update on the Science, Benefits and Cost: Hearing Before the Subcomm. On Environment, Technology and Standards of the House Comm. on Science, 107th Cong., 1st Sess. (Oct. 4, 2001).
  1. Map.
  • Pratt B, Flick P, Vynne C, cartographers. Biodiversity hotspots [map]. Washington: Conservation International; 2000.
  1. Dictionary and similar references.
  • Dorland’s illustrated medical dictionary. 29th ed. Philadelphia: W.B. Saunders; 2000. Filamin; p. 675.
  1. In press.

(Note: NLM prefers “for appearing” because not allways the hole ítems will be pressed)

  • Tian D, Araki H, Stahl E, Bergelson J, Kreitman M. Signature of balancing selection in Arabidopsis. Proc Natl Acad Sci U S A. In press 2002.

Electronic material.

  1. CD-ROOM.
  • Anderson SC, Poulsen KB. Anderson’s electronic atlas of haematology [CD-ROM]. Philadelphia: Lippincott Williams & Wilkins; 2002.
  1. Articles of magazines in the Internet.
  1. Monograph in the Internet.
  • Foley KM, Gelband H, editors. Improving palliative care for cancer [monograph on the Internet]. Washington: National Academy Press; 2001 [cited 2002 Jul 9]. Available in:
  1. Site/page in the web.
  • [homepage on the Internet]. New York: Association of Cancer Online Resources, Inc.; c2000-01 [updated 2002 May 16; cited 2002 Jul 9]. Available in:
  1. Part of a site/page in the web.
  • American Medical Association [homepage on the Internet]. Chicago: The Association; c1995-2002 [updated 2001 Aug 23; cited 2002 Aug 12]. AMA Office of Group Practice Liaison; [about 2 screens]. Available in: category/1736.html
  1. Data base in the Internet.

Opened data base:

  • Who’s Certified [database on the Internet]. Evanston (IL): The American Board of Medical Specialists. c2000 - [cited 2001 Mar 8]. Disponible en:

Closed data base:

  • Jablonski S. Online Multiple Congential Anomaly/ Mental Retardation (MCA/MR) Syndromes [database on the Internet]. Bethesda (MD): National Library of Medicine (US). c1999 [updated 2001 Nov 20; cited 2002 Aug 12]. Disponible en: mesh/jablonski/syndrome_title.html
  1. Part of a data base in the Internet.
  • MeSH Browser [database on the Internet]. Bethesda (MD): National Library of Medicine (US); 2002 - [cited 2003 Jun 10]. Meta-analysis; unique ID: D015201; [about 3 p.]. Available in: http:// Files updated weekly.
MeSH Browser [database on the Internet]. Bethesda (MD): National Library of Medicine (US); 2002 - [cited 2003 Jun 10]. Meta-analysis; unique ID: D015201; [about 3 p.]. Available in: http:// Files updated weekly. Updated July 9, 2003

Remittance by e-mail instructions

For the remittance of the work the next rules must be followed:

Include two pages, in the first one; in the superior and right corner write the full name and address of the author where the correspondence will be sent. If there is more than one author, using small capitals write the first name and last name of each author at length. For this last case in the first page must be written the name and address of the principal author of the work and the names of the collaborators in a second page.

Add a third page with the title of the work in small-case (just the first letter of each word in upper-case); the scientific names must be written in small-case and Italic letters.

If the article is in English, include a fourth page, beginning with the word RESUMEN in upper-case next to the left margin followed by a hyphen with the text in a single paragraph, leave a space and write the words

PALABRAS CLAVE in upper-case, use minimum tree and maximum ten key words, they must be different from those of the title, separated with hyphens and final dots in the last word.

Begin the fifth page with the word ABSTRACT in upper-case next to the left margin followed by a hyphen, writing the text in single paragraph. Do not repeat the title of the work. At the end of the abstract, leave a space, and mention the key-words, following the instructions mentioned for the Resume.

From page six, begin with the Introduction without writing this word. The title must be written in small-case, with the initials in upper-case, in the center with bold-face, without a dot at the end of the introduction.

The following pages must contain Materials and Methods, Results and Discussion. Titles must be written with small-case, with the initials in upper-case, in the center with bold-face, without a dot at the end of each word.

In the next page, if there is any, continue with the Thankfulness, the title must be written with small-case, with the initials in upper-case, in the center and with bold-face.Add the I surrender conflicts of interest.

Begin a new page for the Cited Literature, according with the examples mentioned lines up.

Begin a new page for the tables, each one must be sent in an independent page.

Begin a new page with the list of the legends of the figures. Write the word Figure, just wit the initial in upper-case, followed with the number of the figure and a dot..

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© 2010

Teaching & Biochemistry and Microbiology Investigation Department.

All rights reserved

Carmen Pampa Rural Academic Unit.

“San Pablo” Catholic Bolivian University

Coroico - Nor Yungas – La Paz, Bolivia.

Tel/Fax. 591 (2) 8781991