<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2664-3243</journal-id>
<journal-title><![CDATA[Vive Revista de Salud]]></journal-title>
<abbrev-journal-title><![CDATA[Vive Rev. Salud]]></abbrev-journal-title>
<issn>2664-3243</issn>
<publisher>
<publisher-name><![CDATA[CET-BOLIVIA]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2664-32432021000300009</article-id>
<article-id pub-id-type="doi">10.33996/revistavive.v4i12.105</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Mecanismos de resistencia en aislados clínicos de Klebsiella pneumoniae]]></article-title>
<article-title xml:lang="en"><![CDATA[Resistance mechanisms in clinical isolates of Klebsiella pneumoniae]]></article-title>
<article-title xml:lang="pt"><![CDATA[Mecanismos de resistência em isolados clínicos de Klebsiella pneumoniae]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Merchán Reyes]]></surname>
<given-names><![CDATA[Jenny Jackeline]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gerardo Ortiz]]></surname>
<given-names><![CDATA[Jonnathan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,aff1  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,aff2  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>4</volume>
<numero>12</numero>
<fpage>9</fpage>
<lpage>22</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_arttext&amp;pid=S2664-32432021000300009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_abstract&amp;pid=S2664-32432021000300009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_pdf&amp;pid=S2664-32432021000300009&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La bacteria Klebsiella pneumoniae es la causante de infecciones intrahospitalarias multirresistentes, posee diversos mecanismos de resistencia como la producción de enzimas betalactamasas cuya acción afecta a los antibióticos betalactámicos.  Objetivo:  Caracterizar los mecanismos de resistencia presentes en aislados clínicos con Klebsiella pneumoniae identificados mediante métodos fenotípicos en el Hospital Monte Sinai desde enero de 2018 hasta agosto de 2020.  Materiales y métodos:  Estudio positivista con un enfoque cuantitativo de corte transversal descriptivo de diseño documental. La población estuvo conformada por 274 datos de aislados clínicos identificados con Klebsiella pneumoniae. Los cuales conformaron la totalidad de la muestra con un muestreo por cobertura total. Mismos que fueron recopilados de fuentes secundarias ingresados en la base de datos del departamento de Microbiología. Para el análisis se utilizó estadística descriptiva.  Resultados:  Klebsiella pneumoniae mostró mayor frecuencia en el año 2020 con el 35%. Se identificó al mecanismo de resistencia BLEE con el 27,7% y carbapenemasas tipo KPC con el 7.7 %, con mayor presencia en el sexo masculino. Presentó una mayor resistencia a Penicilinas, una sensibilidad moderada a Cefalosporinas, Aminoglucósidos, Quinolonas y una alta sensibilidad a los Carbapenémicos, Tigeciclina y Colistina. Los aislados se clasificaron como multidrogorresistentes, con mayor frecuencia en Urocultivo, Aspirado bronquial, Líquido corporal, Punta de Catéter y Hemocultivo en áreas de Hospitalización, UCI y Neonatología.  Conclusiones:  Los mecanismos de resistencia de K. pneumoniae a los antibióticos son un hallazgo común en ambientes hospitalarios independientemente de sexo, servicio hospitalario o tipo de muestra, convirtiéndose en un problema de salud pública.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The bacterium Klebsiella pneumoniae is the cause of multiresistant intrahospital infections, it has various resistance mechanisms such as the production of beta-lactamase enzymes whose action affects beta-lactam antibiotics.  Objective:  To characterize the resistance mechanisms present in clinical isolates with Klebsiella pneumoniae identified by phenotypic methods at Monte Sinai Hospital from January 2018 to August 2020.  Materials and methods:  Positivist study with a descriptive cross-sectional quantitative approach to documentary design. The population consisted of 274 data from clinical isolates identified with Klebsiella pneumoniae. Which made up the entire sample with a total coverage sampling. The same ones that were collected from secondary sources entered in the database of the Microbiology department. Descriptive statistics were used for the analysis.  Results:  Klebsiella pneumoniae showed a higher frequency in 2020 with 35%. The ESBL resistance mechanism was identified with 27.7% and KPC-type carbapenemases with 7.7%, with a higher presence in males. It presented a greater resistance to Penicillins, a moderate sensitivity to Cephalosporins, Aminoglycosides, Quinolones and a high sensitivity to Carbapenems, Tigecycline and Colistin. The isolates were classified as multidrug resistant, more frequently in Urine culture, Bronchial aspirate, Body fluid, Catheter Tip and Blood culture in Hospitalization, ICU and Neonatology areas.  Conclusions:  The resistance mechanisms of K. pneumoniae to antibiotics are a common finding in hospital settings regardless of sex, hospital service or type of sample, becoming a public health problem.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo A bactéria Klebsiella pneumoniae é causa de infecções intra-hospitalares multirresistentes, possui diversos mecanismos de resistência como a produção de enzimas beta-lactamase cuja ação afeta os antibióticos beta-lactâmicos.  Objetivo:  Caracterizar os mecanismos de resistência presentes em isolados clínicos de Klebsiella pneumoniae identificados por métodos fenotípicos no Hospital Monte Sinai de janeiro de 2018 a agosto de 2020.  Materiais e métodos:  Estudo positivista com abordagem quantitativa transversal descritiva do design documental. A população consistia em 274 dados de isolados clínicos identificados com Klebsiella pneumoniae. O que constituiu toda a amostra com uma amostra de cobertura total. Os mesmos que foram coletados em fontes secundárias e cadastrados no banco de dados do departamento de Microbiologia. Estatísticas descritivas foram utilizadas para a análise.  Resultados:  Klebsiella pneumoniae apresentou maior frequência em 2020 com 35%. O mecanismo de resistência a ESBL foi identificado com 27,7% e carbapenemases do tipo KPC com 7,7%, com maior presença no sexo masculino. Apresentou maior resistência às Penicilinas, sensibilidade moderada às Cefalosporinas, Aminoglicosídeos, Quinolonas e alta sensibilidade aos Carbapenêmicos, Tigeciclina e Colistina. Os isolados foram classificados como multirresistentes, com maior frequência em Urocultura, Aspirado Brônquico, Fluido Corporal, Ponta de Cateter e Hemocultura em Hospitalização, UTI e Neonatologia.  Conclusões:  Os mecanismos de resistência de K. pneumoniae aos antibióticos são um achado comum em ambientes hospitalares independentemente do sexo, serviço hospitalar ou tipo de amostra, tornando-se um problema de saúde pública.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Klebsiella pneumoniae]]></kwd>
<kwd lng="es"><![CDATA[Betalactamasas]]></kwd>
<kwd lng="es"><![CDATA[Carbapenemasa]]></kwd>
<kwd lng="es"><![CDATA[Infección Hospitalaria]]></kwd>
<kwd lng="es"><![CDATA[Resistencia a los betalactámicos]]></kwd>
<kwd lng="en"><![CDATA[Klebsiella pneumoniae]]></kwd>
<kwd lng="en"><![CDATA[beta-Lactamases]]></kwd>
<kwd lng="en"><![CDATA[Carbapenemase]]></kwd>
<kwd lng="en"><![CDATA[Hospital Infection]]></kwd>
<kwd lng="en"><![CDATA[beta-Lactam Resistance]]></kwd>
<kwd lng="pt"><![CDATA[Klebsiella pneumoniae]]></kwd>
<kwd lng="pt"><![CDATA[Betalactamases]]></kwd>
<kwd lng="pt"><![CDATA[Carbapenemase]]></kwd>
<kwd lng="pt"><![CDATA[Infecção Hospitalar]]></kwd>
<kwd lng="pt"><![CDATA[Resistência aos beta-lactâmicos]]></kwd>
</kwd-group>
</article-meta>
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