<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2664-3243</journal-id>
<journal-title><![CDATA[Vive Revista de Salud]]></journal-title>
<abbrev-journal-title><![CDATA[Vive Rev. Salud]]></abbrev-journal-title>
<issn>2664-3243</issn>
<publisher>
<publisher-name><![CDATA[CET-BOLIVIA]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2664-32432021000200193</article-id>
<article-id pub-id-type="doi">10.33996/revistavive.v4i11.95</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Genes implicados en la gravedad de la infección por SARS-cov- 2]]></article-title>
<article-title xml:lang="en"><![CDATA[Genes involved in the severity of SARS-cov- 2 infection]]></article-title>
<article-title xml:lang="pt"><![CDATA[Genes envolvidos na gravidade da infecção pelo SARS-cov- 2]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tenesaca Serpa]]></surname>
<given-names><![CDATA[Andrea]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Andrade Campoverde]]></surname>
<given-names><![CDATA[Diego]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,aff1  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,aff2  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2021</year>
</pub-date>
<volume>4</volume>
<numero>11</numero>
<fpage>193</fpage>
<lpage>206</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_arttext&amp;pid=S2664-32432021000200193&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_abstract&amp;pid=S2664-32432021000200193&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_pdf&amp;pid=S2664-32432021000200193&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El COVID-19 es una patología producida por el SARS-CoV-2, virus de carácter zoonótico capaz de producir patologías multiorgánicas. La sintomatología que produce es variada. Ante la infección algunos pacientes presentan condiciones de gravedad. Los estudios han demostrado que el rol genético tiene gran afluencia sobre la respuesta ante la infección. El objetivo de investigación es detallar los genes que están implicados en la gravedad de la infección por SARS-CoV- 2.  Metodología . Se realizó una revisión sistemática, con base a la búsqueda y análisis de artículos originales en bases de datos de alto impacto como PudMed, Google Académico, Scopus, Taylor &amp; Francis, ProQuest SciencieDirect; se utilizaron operadores booleanos, criterios de inclusión y exclusión con el objetivo de obtener información precisa. Los genes de inmunidad como el HLA, ACE2 y TMPRSS2 están directamente involucrados con la gravedad de la infección por SARS-CoV- 2. Los polimorfismos de los genes del polyQ del receptor de andrógenos, factor ABO coadyuvan a un deterioro del estado patológico como consecuencia de la COVID-19.  Conclusión.  Los estudios demostraron que existen genes involucrados en la gravedad ante la infección de SARS -CoV-2, pues mencionan que los polimorfismos de los genes; HLA, del polyQ del receptor de andrógenos y factor ABO producen susceptibilidad ante el COVID-19. Así mismo los genes ACE2 y TMPRSS2 intervienen en el ingreso y expansión del virus. En las diversas razas existen variantes de los genes CCL2 y MBL lo que indica que algunas poblaciones son más susceptibles que otras.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract COVID-19 is a pathology caused by SARS-CoV-2, a zoonotic virus capable of producing multi-organ pathologies. The symptomatology it produces is varied. Some patients present severe conditions after infection. Studies have shown that the genetic role has a great influence on the response to infection.  Methodology . A systematic review was carried out, based on the search and analysis of original articles in high impact databases such as PudMed, Google Scholar, Scopus, Taylor &amp; Francis, ProQuest SciencieDirect; Boolean operators, inclusion and exclusion criteria were used in order to obtain accurate information. Immunity genes such as HLA, ACE2 and TMPRSS2 are directly involved with the severity of SARS-CoV- 2 infection. Polymorphisms of androgen receptor polyQ genes, ABO factor contribute to a deterioration of the pathological state as a consequence of COVID-19.  Conclusion . The studies demonstrated that there are genes involved in the severity of SARS-CoV-2 infection, since they mention that polymorphisms of the HLA, androgen receptor polyQ and ABO factor genes produce susceptibility to COVID-19. Likewise, ACE2 and TMPRSS2 genes intervene in the entry and expansion of the virus. In the different breeds there are variants of the CCL2 and MBL genes, which indicates that some populations are more susceptible than others.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo COVID-19 é uma patologia causada pelo SARS-CoV-2, um vírus zoonótico capaz de produzir patologias multiorganismos. Os sintomas que ela produz são variados. Alguns pacientes se apresentam com condições severas após a infecção. Estudos demonstraram que o papel da genética desempenha um papel importante na resposta à infecção. O objetivo desta pesquisa é detalhar os genes que estão envolvidos na gravidade da infecção pelo SARS-CoV- 2.  Metodologia.  Foi realizada uma revisão sistemática, baseada na busca e análise de artigos originais em bancos de dados de alto impacto como PudMed, Google Scholar, Scopus, Taylor &amp; Francis, ProQuest SciencieDirect; operadores booleanos, critérios de inclusão e exclusão foram utilizados para obter informações precisas.  Resultados.  Os genes de imunidade como HLA, ACE2 e TMPRSS2 estão diretamente envolvidos na gravidade da infecção pelo SARS-CoV- 2. Os polimorfismos dos genes receptores de androgênio polyQ, fator ABO contribuem para uma deterioração do estado patológico como conseqüência da COVID-19. Conclusão. Os estudos demonstraram que existem genes envolvidos na gravidade da infecção pelo SRA-CoV-2, pois mencionam que os polimorfismos dos genes HLA, androgênio receptor policarbonato e fator ABO produzem suscetibilidade à COVID-19. Os genes ACE2 e TMPRSS2 também estão envolvidos na entrada e propagação do vírus. Existem variantes dos genes CCL2 e MBL nas diferentes raças, indicando que algumas populações são mais suscetíveis do que outras.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[COVID-19]]></kwd>
<kwd lng="es"><![CDATA[SARS-CoV- 2]]></kwd>
<kwd lng="es"><![CDATA[HLA, TMPRSS2, CCL2, MBL, IL6, polimorfismo, poliglutamina, patogénesis, inmunidad, susceptibilidad, factor ABO]]></kwd>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[SARS-CoV- 2]]></kwd>
<kwd lng="en"><![CDATA[HLA]]></kwd>
<kwd lng="en"><![CDATA[TMPRSS2]]></kwd>
<kwd lng="en"><![CDATA[CCL2]]></kwd>
<kwd lng="en"><![CDATA[MBL]]></kwd>
<kwd lng="en"><![CDATA[IL6]]></kwd>
<kwd lng="en"><![CDATA[polymorphism]]></kwd>
<kwd lng="en"><![CDATA[polyglutamine]]></kwd>
<kwd lng="en"><![CDATA[pathogenesis]]></kwd>
<kwd lng="en"><![CDATA[immunity, susceptibility, ABO factor]]></kwd>
<kwd lng="pt"><![CDATA[COVID-19]]></kwd>
<kwd lng="pt"><![CDATA[SARS-CoV- 2]]></kwd>
<kwd lng="pt"><![CDATA[HLA, TMPRSS2, CCL2, MBL, IL6, polimorfismo, poliglutamina, patogênese, imunidade, suscetibilidade, fator ABO]]></kwd>
</kwd-group>
</article-meta>
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