<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2310-0265</journal-id>
<journal-title><![CDATA[Revista CON-CIENCIA]]></journal-title>
<abbrev-journal-title><![CDATA[Rev.Cs.Farm. y Bioq]]></abbrev-journal-title>
<issn>2310-0265</issn>
<publisher>
<publisher-name><![CDATA[Facultad de Ciencias Farmacéuticas y BioquímicasUniversidad Mayor de San Andrés]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2310-02652024000100016</article-id>
<article-id pub-id-type="doi">10.53287/emws8511qn46h</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Relación del Receptor de Leptina y parámetros metabólicos en población infantojuvenil con sobrepeso y obesidad en el departamento de La Paz]]></article-title>
<article-title xml:lang="en"><![CDATA[Relation between the Leptin Receptor and metabolic parameters in overweight and obese children/adolescents in the Department of La Paz]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Heredia Chucatiny]]></surname>
<given-names><![CDATA[Claudia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alcázar Vásquez]]></surname>
<given-names><![CDATA[Paola Alejandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garcia de Salgueiro]]></surname>
<given-names><![CDATA[Carmiña Heidy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,aff1  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2024</year>
</pub-date>
<volume>12</volume>
<numero>1</numero>
<fpage>16</fpage>
<lpage>27</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_arttext&amp;pid=S2310-02652024000100016&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_abstract&amp;pid=S2310-02652024000100016&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_pdf&amp;pid=S2310-02652024000100016&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción. La obesidad infantil es considerada como uno de los problemas más serios de salud pública. La regulación del peso corporal está dada por la hormona Leptina y su receptor, el cual se afecta cuando se produce resistencia a la Leptina. La comprensión de este desbalance puede ayudarnos a promover estrategias de prevención y reducción de los padecimientos relacionados.  Objetivo. Relacionar el receptor de Leptina (R-Leptina) con parámetros metabólicos (glicemia, perfil lipídico) en población infantojuvenil con sobrepeso y obesidad en el departamento de La Paz.  Materiales y métodos. Para los niveles séricos de: Glicemia, colesterol total, HDL-colesterol y triglicéridos se utilizaron kits comerciales colorimétricos; LDL-colesterol aplicando fórmula de Friedewald; niveles séricos Leptina y R-Leptina mediante ELISA. Se aplicó Test ANOVA para relación entre R-Leptina e IMC; análisis Box-cox para relación Leptina y del R-leptina; correlación de Spearman para relación R-Leptina y parámetros metabólicos (se usó paquetes MASS y ggplot2).  Resultados. Concentraciones de receptor de Leptina por debajo del límite inferior establecido, en pacientes con sobrepeso y obesidad. Solamente la concentración de HDL correlaciona con concentración R-Leptina, en sangre, (&#961;=0.2003, p=0.0040).  Conclusiones. Los pacientes con normopeso tienen mayor concentración sérica del R-Leptina. La concentración parámetros metabólicos está determinada de manera multifactorial]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction. Childhood obesity is considered one of the most serious public health concerns. Leptin, and its receptor, is the hormone responsible of the body weight regulation. Leptin resistance occur when there is an affection to leptin or its receptor. Understanding this imbalance can help us to promote strategies for prevention and reduction of these related conditions.  Objective. To stablish a relation between the Leptin receptor (R-Leptin) with metabolic parameters (glycemia and lipid profile) in overweight and obese children/adolescents in the Department of La Paz.  Materials and methods. To determine blood glucose, total cholesterol, HDL-cholesterol and triglycerides serum levels, commercial colorimetric kits were used. For LDL-cholesterol, Friedewald formula was applied. ELISA test was used for serum Leptin and R-Leptin levels. ANOVA was applied to determine the relation between R-Leptin and BMI; Box-cox analysis for Leptin and R-leptin ratio and; Spearman correlation for R-Leptin ratio and metabolic parameters (MASS and ggplot2 packages were used in R Software version v2.0).  Results. Leptin receptor concentrations below the established lower limit in overweight and obese patients were determined. Only HDL concentration correlated with R-Leptin concentration in blood (&#961;=0.20, p&lt;0.05).  Conclusions. Children/adolescents with normal weight have higher serum concentrations of R-Leptin. The concentration of metabolic parameters was determined in a multifactorial manner.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Obesidad]]></kwd>
<kwd lng="es"><![CDATA[Receptor Leptina]]></kwd>
<kwd lng="es"><![CDATA[Resistencia a la Leptina]]></kwd>
<kwd lng="en"><![CDATA[Obesity]]></kwd>
<kwd lng="en"><![CDATA[Leptin Receptor]]></kwd>
<kwd lng="en"><![CDATA[Leptin Resistance]]></kwd>
</kwd-group>
</article-meta>
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