<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2310-0265</journal-id>
<journal-title><![CDATA[Revista CON-CIENCIA]]></journal-title>
<abbrev-journal-title><![CDATA[Rev.Cs.Farm. y Bioq]]></abbrev-journal-title>
<issn>2310-0265</issn>
<publisher>
<publisher-name><![CDATA[Facultad de Ciencias Farmacéuticas y BioquímicasUniversidad Mayor de San Andrés]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2310-02652021000200103</article-id>
<article-id pub-id-type="doi">10.53287/txcy7580ba27a</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Biosíntesis y mejoramiento de la producción de alcaloides en la familia Amaryllidaceae]]></article-title>
<article-title xml:lang="en"><![CDATA[Review biosynthesis and enhancement of alkaloid production in the Amaryllidaceae family]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ruiz Machicao]]></surname>
<given-names><![CDATA[José Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mollinedo]]></surname>
<given-names><![CDATA[Patricia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Mayor de San Andrés Facultad de Ciencias Puras y Naturales Carrera de Cs. Químicas]]></institution>
<addr-line><![CDATA[La Paz, ]]></addr-line>
<country>Bolivia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>11</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>11</month>
<year>2021</year>
</pub-date>
<volume>9</volume>
<numero>2</numero>
<fpage>103</fpage>
<lpage>116</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_arttext&amp;pid=S2310-02652021000200103&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_abstract&amp;pid=S2310-02652021000200103&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_pdf&amp;pid=S2310-02652021000200103&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La presente revisión bibliográfica referencia diversos estudios que describen la biosíntesis de alcaloides en la familia Amaryllidacea. Se toman en cuenta los procesos enzimáticos que rigen la biosíntesis de los metabolitos secundarios y los métodos de estimulación y mejoramiento de la producción de alcaloides.  Objetivo:  Determinar, mediante una amplia revisión bibliográfica, los posibles métodos de mejora de la producción de alcaloides.  Metodología:  Se realizó una revisión bibliográfica de los documentos más relevantes sobre la biosíntesis de alcaloides de Amaryllidaceae.  Resultados:  En esta revisión, es posible establecer una metodología de mejoramiento de la producción de alcaloides tipo crinina/haemantamina en plantas de la familia Amaryllidaceae nativas de Bolivia y evaluar la posibilidad de aplicarla con éxito para la obtención de mejores rendimientos. ]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  The referenced studies in this bibliographic review show the alkaloid biosynthesis in the Amaryllidaceae family. Some of the processes involved in the improvement and stimulation of alkaloid production are also taken into account and the enzymatic processes that rule secondary metabolites synthesis are described.  Objective:  To determine, through a bibliographic review, possible methods of improving alkaloid production.  Methods:  A wide bibliographic review of the most relevant articles about the Amaryllidaceae family alkaloid production was applied.  Results: It was possible to demonstrate that there is the possibility to stablish and develop a successful method to improve the production of crinine/haemanthamine type alkaloids in the Bolivian native family Amaryllidacea and to evaluate the possibility of applying it successfully to obtain better yields.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Amryllidaceae]]></kwd>
<kwd lng="es"><![CDATA[alcaloides]]></kwd>
<kwd lng="es"><![CDATA[biosíntesis de alcaloides]]></kwd>
<kwd lng="es"><![CDATA[estimulación]]></kwd>
<kwd lng="es"><![CDATA[norbelladina.]]></kwd>
<kwd lng="en"><![CDATA[Amaryllidaceae alkaloids]]></kwd>
<kwd lng="en"><![CDATA[Alkaloid Biosynthesis]]></kwd>
<kwd lng="en"><![CDATA[Stimulation]]></kwd>
<kwd lng="en"><![CDATA[norbelladine.]]></kwd>
</kwd-group>
</article-meta>
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