<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1817-7433</journal-id>
<journal-title><![CDATA[Revista Científica Ciencia Médica]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cient Cienc Méd]]></abbrev-journal-title>
<issn>1817-7433</issn>
<publisher>
<publisher-name><![CDATA[Facultad de Medicina, Universidad Mayor de San Simón.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1817-74332024000100047</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[ADENOCARCINOMA PROSTATICO METASTÁSICO, A PROPÓSITO DE UN CASO]]></article-title>
<article-title xml:lang="en"><![CDATA[METASTATIC PROSTATE ADENOCARCINOMA, ABOUT A CASE]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Orlandoni Rodríguez]]></surname>
<given-names><![CDATA[Juan Pablo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Los Andes  ]]></institution>
<addr-line><![CDATA[Mérida ]]></addr-line>
<country>Venezuela</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<volume>27</volume>
<numero>1</numero>
<fpage>47</fpage>
<lpage>52</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_arttext&amp;pid=S1817-74332024000100047&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_abstract&amp;pid=S1817-74332024000100047&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_pdf&amp;pid=S1817-74332024000100047&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El adenocarcinoma prostático metastásico es una forma avanzada de cáncer de próstata que presenta complicaciones clínicas significativas, especialmente cuando se disemina a la columna vertebral y la vejiga. Esta progresión puede causar dolor intenso, pérdida de función neurológica y problemas urinarios. Este estudio revisa un caso de un paciente de 68 años con adenocarcinoma prostático metastásico que presentó síntomas como dolor lumbar, hematuria, impactación fecal y problemas neurológicos. Se realizaron estudios de imagen como Tomografía Axial Computarizada (TAC) y Resonancia Magnética (RMN), junto con biopsia e inmunohistoquímica, para confirmar el diagnóstico. El tratamiento incluyó radioterapia y bloqueo androgénico. El paciente desarrolló infiltración tumoral en T11 y tejidos blandos, y, aunque se ajustó la radioterapia, el PSA total siguió en aumento. Además, se identificó carcinoma urotelial metastásico en la vejiga. El manejo de estos casos requiere un enfoque multidisciplinario para controlar la expansión metastásica y sus efectos debilitantes.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Metastatic prostate adenocarcinoma is an advanced form of prostate cancer that presents significant clinical complications, especially when it spreads to the spine and bladder. This progression can cause severe pain, neurological dysfunction, and urinary problems. This study reviews the case of a 68-year-old male patient with metastatic prostate adenocarcinoma who presented with symptoms such as lower back pain, hematuria, fecal impaction, and neurological issues. Imaging studies like CT and MRI, along with biopsy and immunohistochemistry, were performed to confirm the diagnosis. Treatment included radiotherapy and androgen blockade. The patient developed tumor infiltration in T11 and soft tissues, and despite adjustments in radiotherapy, total PSA levels continued to rise. Additionally, metastatic urothelial carcinoma was identified in the bladder. Managing these cases requires a multidisciplinary approach to control metastatic spread and its debilitating effects.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Próstata]]></kwd>
<kwd lng="es"><![CDATA[adenocarcinoma]]></kwd>
<kwd lng="es"><![CDATA[metástasis]]></kwd>
<kwd lng="es"><![CDATA[vejiga urinaria]]></kwd>
<kwd lng="es"><![CDATA[neoplasias de la próstata]]></kwd>
<kwd lng="en"><![CDATA[Prostate]]></kwd>
<kwd lng="en"><![CDATA[adenocarcinoma]]></kwd>
<kwd lng="en"><![CDATA[metastasis]]></kwd>
<kwd lng="en"><![CDATA[urinary bladder]]></kwd>
<kwd lng="en"><![CDATA[prostatic neoplasms]]></kwd>
</kwd-group>
</article-meta>
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