<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1817-7433</journal-id>
<journal-title><![CDATA[Revista Científica Ciencia Médica]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cient Cienc Méd]]></abbrev-journal-title>
<issn>1817-7433</issn>
<publisher>
<publisher-name><![CDATA[Facultad de Medicina, Universidad Mayor de San Simón.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1817-74332023000100067</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[CONDUCTO ARTERIOSO PERMEABLE: MECANISMOS MOLECULARES DEL CIERRE Y SU RELACION CON EL TRATAMIENTO]]></article-title>
<article-title xml:lang="en"><![CDATA[PATENT DUCTUS ARTERIOSUS: MOLECULAR MECHANISMS OF CLOSURE AND THEIR RELATIONSHIP WITH THE TREATMENT]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Linares Terrazas]]></surname>
<given-names><![CDATA[Daniel Angel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gomez Webber]]></surname>
<given-names><![CDATA[Micaela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,UMSA Facultad de Medicina Genética Médica]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Bolivia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,UMSA Facultad de Medicina Farmacología]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Bolivia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>26</volume>
<numero>1</numero>
<fpage>67</fpage>
<lpage>76</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_arttext&amp;pid=S1817-74332023000100067&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_abstract&amp;pid=S1817-74332023000100067&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_pdf&amp;pid=S1817-74332023000100067&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El conducto arterioso establece una conexión esencial entre la arteria aorta descendente proximal y la arteria pulmonar principal cerca del origen de la rama pulmonar izquierda, siendo vital durante la vida fetal y generalmente cerrándose poco después del nacimiento en la mayoría de los recién nacidos a término; no obstante, en recien nacidos pretermino, es común la persistencia del conducto arterioso debido a estímulos vasodilatadores que mantienen su permeabilidad y flujo sanguíneo constante, requiriendo enfoques de tratamiento que involucran la inhibición de la prostaglandina E2 y antiinflamatorios no esteroides, aunque la comparación de su eficacia con métodos conservadores sigue siendo poco clara, especialmente en recién nacidos prematuros extremos. La presente revisión tiene como objetivo proporcionar una comprensión de los mecanismos moleculares clave detrás de la fisiopatología del conducto arterioso persistente y su abordaje terapéutico.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT The ductus arteriosus establishes an essential connection between the proximal descending aorta and the main pulmonary artery near the origin of he left pulmonary branch, being vital during fetal life and generally closing shortly after birth in most term newborns; However, in preterm infants, persistence of the ductus arteriosus is common due to vasodilator stimuli that maintain its patency and constant blood flow, requiring treatment approaches involving prostaglandin E2 inhibition and nonsteroidal anti-inflammatory drugs, although the comparison of their efficacy with conservative methods remains unclear, especially in extremely preterm infants. The present review aims to provide an understanding of the key molecular mechanisms behind the pathophysiology of patent ductus arteriosus and its therapeutic approach.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Conducto Arterioso Permeable]]></kwd>
<kwd lng="es"><![CDATA[Recien Nacido Prematuro]]></kwd>
<kwd lng="es"><![CDATA[Prostaglandinas]]></kwd>
<kwd lng="es"><![CDATA[Ibuprofeno]]></kwd>
<kwd lng="en"><![CDATA[Patent Ductus Arteriosus]]></kwd>
<kwd lng="en"><![CDATA[Premature Infant]]></kwd>
<kwd lng="en"><![CDATA[Prostaglandins]]></kwd>
<kwd lng="en"><![CDATA[Ibuprofen]]></kwd>
</kwd-group>
</article-meta>
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