<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1817-7433</journal-id>
<journal-title><![CDATA[Revista Científica Ciencia Médica]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cient Cienc Méd]]></abbrev-journal-title>
<issn>1817-7433</issn>
<publisher>
<publisher-name><![CDATA[Facultad de Medicina, Universidad Mayor de San Simón.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1817-74332022000200168</article-id>
<article-id pub-id-type="doi">10.51581/rccm.v25i2.515</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[MARCADORES FGF-23 Y KLOTHO EN enfermedad renal CRÓNICA Y SU IMPLICACIÓN CARDIOVASCULAR, UNA REVISIÓN SISTEMÁTICA]]></article-title>
<article-title xml:lang="en"><![CDATA[FGF-23 AND KLOTHO MARKERS IN CHRONIC KIDNEY DISEASE AND ITS CARDIOVASCULAR IMPLICATION, A SYSTEMATIC REVIEW]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Yax-Batz]]></surname>
<given-names><![CDATA[Edy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mazariegos]]></surname>
<given-names><![CDATA[Luis Felipe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Mariano Gálvez Medicina ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<volume>25</volume>
<numero>2</numero>
<fpage>168</fpage>
<lpage>173</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_arttext&amp;pid=S1817-74332022000200168&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_abstract&amp;pid=S1817-74332022000200168&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_pdf&amp;pid=S1817-74332022000200168&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La principal causa de mortalidad en enfermedad renal crónica (ERC), en el 80% de pacientes se da por enfermedad cardiovascular asociada, los parámetros bioquímicos clásicos del metabolismo óseomineral aún no logran explicar la progresión patológica por tanto, se ha empezado a estudiar nuevos marcadores con relación al daño cardiovascular, donde se ha encontrado al marcador FGF-23 y su correceptor Klotho, implicados en la génesis del daño cardiovascular y enfermedad óseomineral asociada al fosforo, que en conjunto causan remodelamiento cardiovascular, lo que ha empezado aclarecer aún más esta dinámica fisiopatológica. Esta revision busca conocer la implicación de los marcadores FGF-23 y Klotho en ERC y el riesgo cardiovascular asociado y para ello realizó una revision sistemática de literatura, indagando en bases biomédicas como COCHRANE, Embase, LILACS, Scielo, Pub-Med, EBSCO, Hinari, Sociedades médicas, así como tesauros MeSH propios de esta investigación.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT The main cause of mortality in chronic kidney disease (CKD), in 80% of patients, is due to associated cardiovascular disease, the classic biochemical parameters of bone-mineral metabolism will not yet be able to explain the pathological progression, therefore, new markers have begun to be studied in relation to cardiovascular damage, where the marker FGF-23 and its co-receptor Klotho have been found, involved in the genesis of cardiovascular damage and bone-mineral disease associated with phosphorus, which together cause cardiovascular remodeling , which has begun to further clarify this pathophysiological dynamic. This review seeks to know the implication of the FGF-23 and Klotho markers in CKD and the associated cardiovascular risk and for this purpose, a systematic review of the literature was carried out, investigating biomedical bases such as COCHRANE, Embase, LILACS, Scielo, Pub-Med, EBSCO, Hinari, Medical Societies, as well as MeSH thesauri specific to this research.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[CKD-MBD]]></kwd>
<kwd lng="es"><![CDATA[Factor-23 de Crecimiento de Fibroblastos]]></kwd>
<kwd lng="es"><![CDATA[Osteodistrofia renal]]></kwd>
<kwd lng="en"><![CDATA[CKD-MBD]]></kwd>
<kwd lng="en"><![CDATA[Fibroblast growth factor-23]]></kwd>
<kwd lng="en"><![CDATA[Renal osteodystrophy]]></kwd>
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