<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1726-8958</journal-id>
<journal-title><![CDATA[Revista Médica La Paz]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Méd. La Paz]]></abbrev-journal-title>
<issn>1726-8958</issn>
<publisher>
<publisher-name><![CDATA[Colegio Médico de La Paz]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1726-89582024000200048</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[DEFICIENCIA PRIMARIA DE IGG SUBCLASE-3 ASOCIADA A GRANULOMATOSIS CON POLIANGEITIS, A PROPÓSITO DE UN CASO]]></article-title>
<article-title xml:lang="en"><![CDATA[PRIMARY IGG SUBCLASS-3 DEFICIENCY ASSOCIATED WITH GRANULOMATOSIS WITH POLYANGEITIS, RELATING TO A CASE]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guachalla Castro]]></surname>
<given-names><![CDATA[Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quispe Rodríguez]]></surname>
<given-names><![CDATA[Mónica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Obrero N 1 Inmunología y Alergología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,Medicina Interna  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<volume>30</volume>
<numero>2</numero>
<fpage>48</fpage>
<lpage>51</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_arttext&amp;pid=S1726-89582024000200048&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_abstract&amp;pid=S1726-89582024000200048&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_pdf&amp;pid=S1726-89582024000200048&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Las enfermedades vasculiticas se complican frecuentemente con infecciones pulmonares, como en el presente caso clínico donde tratamos a un paciente con granulomatosis con poliangeitis, con cuadro clínico de neumonía de difícil tratamiento por falta de respuesta a la terapia antibacteriana de amplio espectro. Esto nos lleva a replantear diagnósticos diferenciales haciendo hincapié en que la causa de base sea otra enfermedad asociada, como una inmunodeficiencia primaria o secundaria más prevalente en la edad adulta. Haciendo un análisis clínico exhaustivo llegamos a la conclusión de una deficiencia primaria de IgG subclase-3. El paciente recibió terapia de remplazo de inmunoglobulina con mejoría clínica.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Vasculitic diseases are frequently complicated by lung infections, as in the present clinical case where we treated a patient with granulomatosis with polyangiitis, with a clinical picture of pneumonia that is difficult to treat due to lack of response to broad- spectrum antibacterial therapy. This leads us to reconsider differential diagnoses, emphasizing that the underlying cause is another associated disease, such as a primary or secondary immunodeficiency that is more prevalent in adulthood. Doing a thorough clinical analysis we came to the conclusion of a primary deficiency of IgG subclass-3. The patient received immunoglobulin replacement therapy with clinical improvement.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Deficiencia de IgG subclase-3]]></kwd>
<kwd lng="es"><![CDATA[vasculitis]]></kwd>
<kwd lng="es"><![CDATA[inmunodeficiencia]]></kwd>
<kwd lng="en"><![CDATA[IgG subclass-3 deficiency]]></kwd>
<kwd lng="en"><![CDATA[vasculitis]]></kwd>
<kwd lng="en"><![CDATA[immunodeficiency]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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