<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1726-8958</journal-id>
<journal-title><![CDATA[Revista Médica La Paz]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Méd. La Paz]]></abbrev-journal-title>
<issn>1726-8958</issn>
<publisher>
<publisher-name><![CDATA[Colegio Médico de La Paz]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1726-89582024000100020</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[EPIDEMIOLOGIA DE LA LEUCEMIA NEONATAL EN BOLIVIA]]></article-title>
<article-title xml:lang="en"><![CDATA[EPIDEMIOLOGY OF NEONATAL LEUKEMIA IN BOLIVIA]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cruz]]></surname>
<given-names><![CDATA[Karla]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Salas]]></surname>
<given-names><![CDATA[Beatriz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojas]]></surname>
<given-names><![CDATA[Gerardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mamani]]></surname>
<given-names><![CDATA[Luis Felipe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lazo]]></surname>
<given-names><![CDATA[Cristian]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Luna]]></surname>
<given-names><![CDATA[Julieta]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Patón]]></surname>
<given-names><![CDATA[Daniela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Amaru]]></surname>
<given-names><![CDATA[Ricardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital de Niños Dr. Mario Ortiz Suarez  ]]></institution>
<addr-line><![CDATA[Santa Cruz ]]></addr-line>
<country>Bolivia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital del Niño &#8216;Manuel Ascencio Villarroel&#8217;  ]]></institution>
<addr-line><![CDATA[Cochabamba ]]></addr-line>
<country>Bolivia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Municipal de Santa Cruz  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Bolivia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,UMSA Facultad de Medicina Unidad de Biología Celular]]></institution>
<addr-line><![CDATA[La Paz ]]></addr-line>
<country>Bolivia</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Hospital Viedma  ]]></institution>
<addr-line><![CDATA[Cochabamba ]]></addr-line>
<country>Bolivia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<volume>30</volume>
<numero>1</numero>
<fpage>20</fpage>
<lpage>26</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_arttext&amp;pid=S1726-89582024000100020&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_abstract&amp;pid=S1726-89582024000100020&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_pdf&amp;pid=S1726-89582024000100020&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción.  La leucemia neonatal se presenta durante las cuatro primeras semanas de vida extrauterina, corresponde al 1% de todas las leucemias pediátricas. Se caracteriza por leucemogénesis en útero y está relacionada con la genotoxicidad y el medio ambiente contaminado. La leucemia mieloide aguda representa la gran mayoría de los casos (60%), las alteraciones cromosómicas afectan a la región 11q23. La infiltración cutánea leucémica, la hepatoesplenomegalia y la leucocitosis mayor a 100.000/ul son signos comunes en esta enfermedad.  Objetivo.  Determinar las características epidemiológicas de la leucemia neonatal en Bolivia.  Material y métodos.  Estudio descriptivo retrospectivo de leucemias neonatales diagnosticadas entre 2007 y 2023. Se recolectó datos epidemiológicos concernientes a características clínicas, características morfológicas e immunofenotípicas, resultados de laboratorio correspondientes al momento del diagnóstico y seguimiento, así como, la radicatoria de la madre durante la gestación.  Resultados.  Se evidenció 13 casos, la edad media neonatal fue 20 días y mayor incidencia en neonatos varones (n=9, 69%). La LMA (9 casos, 69 %) fue el tipo de leucemia más frecuente (subtipo preponderante LMA M7), seguida de la LLA-B (n=4). 7 casos fueron procedentes de Santa Cruz (54 %), 3 de Cochabamba (23 %), sucesivamente La Paz, Beni y Chuquisaca con un caso cada uno (23 %). Leucocitosis media 106.000/ul, hemoglobina media 13,2 g/dl y plaquetas 209.000/ul fueron características laboratoriales.  Conclusiones.  La incidencia de leucemia neonatal en Santa Cruz y Cochabamba constituye un interés de salud pública, lo que demanda escudriñar sobre factores de riesgo relacionados con su etiología y el impacto de la contaminación del medio ambiente en esas regiones.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction.  Neonatal leukemia occurs during the first four weeks after birth, corresponding to 1% of all pediatric leukemias. It is characterized byleukemogenesis in the uterus, which is related to genotoxicity and polluted environment. Acute myeloid leukemia representas the vast majority of cases (60%), chromosomal alterations concerning 11q23 region. Common signs involve leukemia cutis, hepatosplenomegaly and leukocytosis higher than 100,000/ul.  Objective.  To determine the epidemiological characteristics of neonatal leukemia in Bolivia.  Material and methods.  Retrospective descriptive study of neonatal leukemias diagnosed between 2007 and 2023. Epidemiological data regarding clinical characteristics, morphological and immunophenotypic features, laboratory results at diagnosis and follow-up, as well as, residency of the mother during pregnancy were collected.  Results.  A total of 13 cases were evidenced, mean neonatal age was 20 days, with a higher incidence in male neonates (n=9, 69%). AML (9 cases, 69%) was the most common type of leukemia (mainly AML M7 subtype), followed by B-ALL (n=4). 7 cases were from Santa Cruz (54%), 3 from Cochabamba (23%), consecutively La Paz, Beni and Chuquisaca with 1 case each (23%). Laboratory characteristics displayed mean leukocytosis of106,000/ul, mean Hb 13,2 g/dl and platelets 209.000/ ul.  Conclusions.  The incidence of neonatal leukemia in Santa Cruz and Cochabamba stands a public health interest, which requires scrutinizing risk factors related to its etiology and the impact of environmental pollution in those region.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Leucemia neonatal]]></kwd>
<kwd lng="es"><![CDATA[medio ambiente]]></kwd>
<kwd lng="es"><![CDATA[genotoxicidad, Bolivia]]></kwd>
<kwd lng="en"><![CDATA[Neonatal leukemia]]></kwd>
<kwd lng="en"><![CDATA[environment]]></kwd>
<kwd lng="en"><![CDATA[genotoxicity, Bolivia]]></kwd>
</kwd-group>
</article-meta>
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