<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1726-8958</journal-id>
<journal-title><![CDATA[Revista Médica La Paz]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Méd. La Paz]]></abbrev-journal-title>
<issn>1726-8958</issn>
<publisher>
<publisher-name><![CDATA[Colegio Médico de La Paz]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1726-89582024000100014</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[ELEVADA PREVALENCIA DE MALFORMACIONES ANORRECTALES EN RECIÉN NACIDOS A GRAN ALTITUD]]></article-title>
<article-title xml:lang="en"><![CDATA[INCREASED PREVALENCE OF ANORECTAL MALFORMATIONS IN NEWBORNS AT HIGH ALTITUDE]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jiménez]]></surname>
<given-names><![CDATA[Gabriela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Luna]]></surname>
<given-names><![CDATA[Beatriz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Linares]]></surname>
<given-names><![CDATA[Daniel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Paz]]></surname>
<given-names><![CDATA[Rolando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Taboada]]></surname>
<given-names><![CDATA[Gonzalo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Mayor de San Andrés Instituto de Genética ]]></institution>
<addr-line><![CDATA[La Paz ]]></addr-line>
<country>Bolivia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<volume>30</volume>
<numero>1</numero>
<fpage>14</fpage>
<lpage>19</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_arttext&amp;pid=S1726-89582024000100014&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_abstract&amp;pid=S1726-89582024000100014&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_pdf&amp;pid=S1726-89582024000100014&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción.  Las malformaciones anorrectales son un grupo de anomalías congénitas de etiología multifactorial, en las que intervienen diversos factores genéticos y ambientales. Los habitantes de regiones de gran altitud están expuestos a hipoxia hipobárica crónica, lo que se ha asociado a una mayor prevalencia de varias anomalías congénitas.  Objetivo.  El objetivo del estudio es investigar la prevalencia al nacimiento de malformaciones anorrectales en La Paz, Bolivia.  Material y métodos.  Se realizó un estudio transversal. Los casos fueron recolectados en el Hospital de la Mujer ubicado en La Paz, Bolivia, a una altitud promedio de 3600 metros sobre el nivel del mar.  Resultados.  De 56206 nacidos vivos registrados durante el periodo de estudio, 30 recién nacidos presentaban malformaciones anorrectales, lo que arrojaba una prevalencia de 5,34 por 10000 nacidos vivos. Esta prevalencia era superior a la prevalencia de 3 por 10000 nacidos vivos registrada anteriormente en la literatura.  Conclusiones.  Nuestro estudio muestra que la prevalencia de malformaciones anorrectales es mayor en la población de altura de La Paz, Bolivia, en comparación con la prevalencia previamente reportada en la literatura. Se necesitan más investigaciones para identificar los factores genéticos y ambientales subyacentes que contribuyen a esta mayor prevalencia, además de mejorar el diagnóstico y los sistemas de vigilancia.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction.  Anorectal matformations are a group of congenital anomalies that have a multifactorial etiology, involving various genetic and environmental factors. Inhabitants living at high-altitude regions are exposed to chronic hypobaric hypoxia, which has been associated with a higher prevalence of congenital anomalies.  Objective.  It was aimed to investígate the prevalence of anorectal malformations in newborns from La Paz, Bolivia.  Material and methods.  We conducted a cross-sectional study. Newborns data were collected at the Hospital de la Mujer located in La Paz, Bolivia, at an average altitude of 3600 masl.  Results.  Out of 56,206 live births were registered during the study period. 30 newborns had anorectal malformations, resulting in a prevalence of 5.34 per 10,000 live births. This prevalence was higher than the previously reported in the literature, 3 per 10,000 live births.  Conclusions.  Our study depicts the prevalence of anorectal malformations is higher in the population of La Paz-Bolivia living at high-altitude, this when compared to previously reported prevalence in the literature. Further research is needed to identify the underlying genetic and environmental factors that contribute to this increased prevalence, as well as to improve diagnosis and monitoring systems.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Malformaciones anorrectales]]></kwd>
<kwd lng="es"><![CDATA[Epidemiologia]]></kwd>
<kwd lng="es"><![CDATA[Bolivia]]></kwd>
<kwd lng="es"><![CDATA[Gran altitud]]></kwd>
<kwd lng="en"><![CDATA[Anorectal malformation]]></kwd>
<kwd lng="en"><![CDATA[Epidemiology]]></kwd>
<kwd lng="en"><![CDATA[Bolivia]]></kwd>
<kwd lng="en"><![CDATA[High-altitude]]></kwd>
</kwd-group>
</article-meta>
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