<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1726-8958</journal-id>
<journal-title><![CDATA[Revista Médica La Paz]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Méd. La Paz]]></abbrev-journal-title>
<issn>1726-8958</issn>
<publisher>
<publisher-name><![CDATA[Colegio Médico de La Paz]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1726-89582023000100084</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[BIOMARCADORES TEMPRANOS EN NEFROPATIA DIABÉTICA]]></article-title>
<article-title xml:lang="en"><![CDATA[EARLY BIOMARKER IN DIABETIC NEPHROPATHY]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Henao Sanjinés]]></surname>
<given-names><![CDATA[Milenca Valentina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Urquizo Ayala]]></surname>
<given-names><![CDATA[Guillermo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital de Clínicas  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital de Clínicas Unidad de Medicina ]]></institution>
<addr-line><![CDATA[La Paz ]]></addr-line>
<country>Bolivia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>29</volume>
<numero>1</numero>
<fpage>84</fpage>
<lpage>86</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_arttext&amp;pid=S1726-89582023000100084&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_abstract&amp;pid=S1726-89582023000100084&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_pdf&amp;pid=S1726-89582023000100084&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La enfermedad renal diabética es una patología de presentación frecuente y una costosa complicación de la diabetes. Se considera una de las principales causas de insuficiencia renal e ingreso a Terapia de Reemplazo renal. En la práctica clínica, la enfermedad renal diabética se diagnostica por albuminuria, una disminución de la tasa de filtración glomerular estimada (eGFR), o ambos. Actualmente existe la posibilidad de detectar varios marcadores tempranos, como el CKD273, el mismo que se asoció con un mayor riesgo de progresión a microalbuminuria, siendo una alerta temprana de presentación de nefropatía diabetica, varios años antes de su presentación.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[SUMMARY Diabetic kidney disease is a common presenting condition and a costly complication of diabetes. It is considered one of the main causes of renal failure and admission to renal replacement therapy. In clinical practice, diabetic kidney disease is diagnosed by albuminuria, a decrease in estimated glomerular filtration rate (eGFR), or both. Currently, there is the possibility of detecting early markers such as CKD273, which was associated with an increased risk of progression to microalbuminuria, being an early warning of the presentation of diabetic nephropathy, several years before its presentation.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Biomarcador]]></kwd>
<kwd lng="es"><![CDATA[nefropatía diabética, microalbuminuria]]></kwd>
<kwd lng="en"><![CDATA[Biomarker]]></kwd>
<kwd lng="en"><![CDATA[diabetic nephropathy, microalbuminuria]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[Jin]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[Jianhua]]></given-names>
</name>
<name>
<surname><![CDATA[Qin]]></surname>
<given-names><![CDATA[Xiaosong]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Advances in early biomarkers of diabetic nephropathy]]></article-title>
<source><![CDATA[Revista da Associação Médica Brasileira]]></source>
<year>2018</year>
<volume>64</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>85-92</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Papadopoulou-Marketou]]></surname>
<given-names><![CDATA[Nektaria]]></given-names>
</name>
<name>
<surname><![CDATA[Kanaka-Gantenbein]]></surname>
<given-names><![CDATA[Christina]]></given-names>
</name>
<name>
<surname><![CDATA[Marketos]]></surname>
<given-names><![CDATA[Nikolaos]]></given-names>
</name>
<name>
<surname><![CDATA[George]]></surname>
<given-names><![CDATA[P. Chrousos]]></given-names>
</name>
<name>
<surname><![CDATA[Papassotiriou]]></surname>
<given-names><![CDATA[Ioannis]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Biomarkers of diabetic nephropathy: A 2017 update]]></article-title>
<source><![CDATA[Critical Reviews in Clinical Laboratory Sciences]]></source>
<year>2017</year>
<volume>54</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>326-42</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Khan]]></surname>
<given-names><![CDATA[N.U.]]></given-names>
</name>
<name>
<surname><![CDATA[Lin]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[X.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Insights into predicting diabetic nephropathy using urinary biomarkers]]></article-title>
<source><![CDATA[BBA - Proteins and Proteomics]]></source>
<year>2020</year>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Thipsawat]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Early detection of diabetic nephropathy in patient with type 2 diabetes mellitus: A review of the literature]]></article-title>
<source><![CDATA[Diab Vasc Dis Res]]></source>
<year>2021</year>
<volume>18</volume>
<numero>6</numero>
<issue>6</issue>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Van]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Scholey]]></surname>
<given-names><![CDATA[JW]]></given-names>
</name>
<name>
<surname><![CDATA[Konvalinka]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Insights into Diabetic Kidney Disease Using Urinary Proteomics and Bioinformatics]]></article-title>
<source><![CDATA[J Am Soc Nephrol]]></source>
<year>2017</year>
<volume>28</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>1050-61</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Currie]]></surname>
<given-names><![CDATA[G.E.]]></given-names>
</name>
<name>
<surname><![CDATA[von Scholten]]></surname>
<given-names><![CDATA[B.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Mary]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Urinary proteomics for prediction of mortality in patients with type 2 diabetes and microalbuminuria]]></article-title>
<source><![CDATA[Cardiovasc Diabetol]]></source>
<year>2018</year>
<volume>17</volume>
<numero>50</numero>
<issue>50</issue>
<page-range>1050-61</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tofte]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Lindhardt]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Adamova]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Bakker]]></surname>
<given-names><![CDATA[SJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[PRIORITY investigators. Early detection of diabetic kidney disease by urinary proteomics and subsequent intervention with spironolactone to delay progression (PRIORITY): a prospective observational study and embedded randomized placebo-controlled trial]]></article-title>
<source><![CDATA[Lancet Diabetes Endocrinol]]></source>
<year>2020</year>
<volume>8</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>301-12</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fernández-Fernández]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Ortiz]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<collab>IIS-Fundación Jiménez Díaz</collab>
<article-title xml:lang=""><![CDATA[Biomarcadores en enfermedad renal diabética:10 respuestas que un nefrólogo debe conocer]]></article-title>
<source><![CDATA[Madrid NefroPlus]]></source>
<year>2020</year>
<volume>12</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-7</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
