<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1726-8958</journal-id>
<journal-title><![CDATA[Revista Médica La Paz]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Méd. La Paz]]></abbrev-journal-title>
<issn>1726-8958</issn>
<publisher>
<publisher-name><![CDATA[Colegio Médico de La Paz]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1726-89582023000100044</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[COMPARACIÓN DE LA SEGURIDAD DE SEDOANALGESIA ENTRE PROPOFOL-FENTANILO VS PROPOFOL-KETAMINA EN PACIENTES CON COVID-19 SOMETIDOS A COLONOSCOPIAS]]></article-title>
<article-title xml:lang="en"><![CDATA[SAFETY COMPARISON BETWEEN PROPOFOL-FENTANYL VS PROPOFOL-KETAMINE SEDOANALGESIA IN PATIENTS WITH COVID-19 WHO UNDERWENT COLONOSCOPIES]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Torrez Santos]]></surname>
<given-names><![CDATA[Eynar Rodrigo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vallejos Mita]]></surname>
<given-names><![CDATA[Gloria Martha]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Municipal Modelo Corea Cirugía Gastroenterológica ]]></institution>
<addr-line><![CDATA[Ciudad de El Alto ]]></addr-line>
<country>Bolivia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto de Gastroenterología Boliviano Japonés Cirugía Gastroenterológica ]]></institution>
<addr-line><![CDATA[La Paz Ciudad La Paz]]></addr-line>
<country>Bolivia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>29</volume>
<numero>1</numero>
<fpage>44</fpage>
<lpage>51</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_arttext&amp;pid=S1726-89582023000100044&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_abstract&amp;pid=S1726-89582023000100044&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_pdf&amp;pid=S1726-89582023000100044&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: Los procedimientos anestésicos fuera de quirófano se han incrementado. Ahora se añade el reto del manejo del paciente con COVID-19, dentro de estos esta la colonoscopia que debe realizarse bajo sedoanalgesia, no se cuenta con un fármaco ideal por lo que se realizan combinaciones para la seguridad del paciente y personal de salud.  Objetivo: Comparar la seguridad de sedoanalgesia con propofol-fentanilo vs propofol-ketamina en pacientes con COVID-19 sometidos a colonoscopia.  Material y métodos: Se realizó un estudio experimental, transversal, comparativo con 60 pacientes sometidos a colonoscopia, estos fueron seleccionados por sucesión en 2 grupos: grupo A (propofol-fentanil) y grupo B (propofol-ketamina). Grupo A: fentanil 1 ug/kg y posteriormente propofol a 0,5 a 1,5 mg/kg, y mantenimiento con bolos de propofol a 0,5 mg/kg. Grupo B: se preparó mezcla de propofol-ketamina a proporción de 4:1, en la inducción se utilizó propofol (1mg/kg) y ketamina (0,25mg/kg), mantenimiento propofol (5 mg/kg/h) y ketamina (1,25 mg/kg/h). La información fue recolectada de fuentes primarias, se empleó el programa estadístico SPSS versión 22.0.  Resultados: El grupo A tuvo tendencia a la bradicardia e hipotensión, además de mayor depresión respiratoria con una frecuencia de 4 (13,3%) en relación a 1 (3,3%) en el grupo ketofol.  Conclusión: el ketofol demostró ser más seguro en comparación a propofol- fentanil para la sedoanalgesia en colonoscopia de pacientes COVID-19.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Anesthetic procedures outside the operating room have increased. Now the challenge of managing patients with COVID-19 is included, within these is the colonoscopy that must be performed under sedo-analgesia, there is no an ideal drug so combinations are made for the safety of the patient and the health staff.  Objective:  To compare the safety of sedo-analgesia with propofol-fentanyl vs propofol-ketamine in patients with COVID-19 undergoing colonoscopy.  Material and methods:  An experimental, cross-sectional, comparative study was carried out in 60 patients submitted to colonoscopy, these were selected by succession into 2 groups: group A (propofol-fentanyl) and group B (propofol- ketamine). Group A: fentanyl 1 ug/kg and later propofol at 0.5 to 1.5 mg/kg, and maintenance with propofol boluses at 0.5 mg/kg. Group B: a mixture of propofol- ketamine was prepared at a ratio of 4:1, in induction propofol (1 mg/kg) and ketamine (0.25 mg/kg) were used, propofol maintenance (5 mg/kg/h) and ketamine (1.25 mg/ kg/h). The information was collected from primary sources, the statistical program SPSS version 22.0 was used.  Results:  Group A had a tendency to bradycardia and hypotension, as well as greater respiratory depression with a frequency of 4 (13.3%) in relation to 1 (3.3%) in the ketofol group.  Conclusion:  Ketofol has shown to be safer compared to propofol-fentanyl for colonoscopy sedo-analgesia in COVID-19 patients.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[sedoanalgesia]]></kwd>
<kwd lng="es"><![CDATA[ketofol]]></kwd>
<kwd lng="es"><![CDATA[fentanyl]]></kwd>
<kwd lng="es"><![CDATA[ketamine]]></kwd>
<kwd lng="es"><![CDATA[COVID-19]]></kwd>
<kwd lng="es"><![CDATA[colonoscopia]]></kwd>
<kwd lng="en"><![CDATA[sedo-analgesia]]></kwd>
<kwd lng="en"><![CDATA[ketofol]]></kwd>
<kwd lng="en"><![CDATA[fentanyl]]></kwd>
<kwd lng="en"><![CDATA[ketamine]]></kwd>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[colonoscopy]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mejía]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Anestesia fuera de quirófano]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Carrillo]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Anestesiología de las bases a la práctica]]></source>
<year>2019</year>
<edition>1</edition>
<page-range>673-80</page-range><publisher-loc><![CDATA[México ]]></publisher-loc>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Oramas]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Massip]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Navarrete]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Wilson]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Propofol-fentanyl bolus versus ketofol continuous infusión for sedation-analgesia in elective colonoscopy]]></article-title>
<source><![CDATA[Revista Cubana de Anestesiología y Reanimación]]></source>
<year>2018</year>
<volume>17</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Soto]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Salazar]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Añez]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Espinoza]]></surname>
<given-names><![CDATA[CI]]></given-names>
</name>
<name>
<surname><![CDATA[Valle]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
<name>
<surname><![CDATA[Velasco]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sedoanalgesia con ketofol vs propofol-fentanilo en pacientes sometidos a procedimientos endoscópicos]]></article-title>
<source><![CDATA[Venezolanos de Farmacología y Terapéutica]]></source>
<year>2018</year>
<volume>38</volume>
<numero>2</numero>
<issue>2</issue>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zamora r]]></surname>
<given-names><![CDATA[Dafne Denisse]]></given-names>
</name>
<name>
<surname><![CDATA[Rendón]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Barajas]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Villarreal]]></surname>
<given-names><![CDATA[GJ]]></given-names>
</name>
<name>
<surname><![CDATA[Palacios]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez]]></surname>
<given-names><![CDATA[NH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ketamina-Propofol vs Propofol para sedación en endoscopia digestiva superior]]></article-title>
<source><![CDATA[Anestesia en México]]></source>
<year>2016</year>
<volume>28</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>13-9</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tian]]></surname>
<given-names><![CDATA[Liang]]></given-names>
</name>
<name>
<surname><![CDATA[Luan]]></surname>
<given-names><![CDATA[Hengfei]]></given-names>
</name>
<name>
<surname><![CDATA[Zhu]]></surname>
<given-names><![CDATA[Pin]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[Zhiyuan]]></given-names>
</name>
<name>
<surname><![CDATA[Bao]]></surname>
<given-names><![CDATA[Hongguang]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A randomized controlled trial for measuring effects on cognitive functions of adding ketamine to propofol during sedation for colonoscopy]]></article-title>
<source><![CDATA[Medicine]]></source>
<year>2020</year>
<volume>99</volume>
<page-range>36</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Otero]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Gómez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Ángel]]></surname>
<given-names><![CDATA[LA]]></given-names>
</name>
<name>
<surname><![CDATA[Ruiz]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Marulanda]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Riveros]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Procedimientos endoscópicos y pandemia COVID-19 Consideraciones básicas]]></article-title>
<source><![CDATA[Rev Colomb Gastroenterologia]]></source>
<year>2020</year>
<volume>35</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>65-75</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Estrada]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Barreda]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<name>
<surname><![CDATA[Leyva]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Sánchez]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Uso de ketaminapropofol en la colonoscopia ambulatoria diagnóstica terapéutica]]></article-title>
<source><![CDATA[Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta]]></source>
<year>2017</year>
<volume>42</volume>
<numero>6</numero>
<issue>6</issue>
</nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Suárez Aguilar]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Recomendaciones para sedación fuera de quirófano en la pandemia de la COVID-19]]></article-title>
<source><![CDATA[Colombian journal of anesthesiology]]></source>
<year>2020</year>
<volume>48</volume>
<numero>4</numero>
<issue>4</issue>
</nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pellecer González]]></surname>
<given-names><![CDATA[LC]]></given-names>
</name>
<name>
<surname><![CDATA[Guillén Rojas]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[COVID-19 Evaluación y manejo de la anestesia para procedimientos endoscópicos gastrointestinales]]></article-title>
<source><![CDATA[Revista Chilena de Anestesiología]]></source>
<year>2020</year>
<volume>49</volume>
<page-range>p</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Molano-Caro]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Borrero-Cortés]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Lizarazo-Rodríguez]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Gómez-Chacón]]></surname>
<given-names><![CDATA[NE]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Retorno a la actividad asistencial en el contexto de COVID-19: priorización, protocolos y procedimientos. Experiencia de una unidad de gastroenterología ambulatoria en Bogotá, Colombia]]></article-title>
<source><![CDATA[Revista Colombiana de Gastroenterologia]]></source>
<year>2020</year>
<volume>35</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>287-97</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sánchez García]]></surname>
<given-names><![CDATA[NL]]></given-names>
</name>
<name>
<surname><![CDATA[Infante Velázquez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Endoscopia digestiva durante la pandemia del COVID-19]]></article-title>
<source><![CDATA[Revista de la Habana ciencias médicas]]></source>
<year>2020</year>
<volume>19</volume>
</nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Torres Mesa]]></surname>
<given-names><![CDATA[PA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Endoscopia digestiva en tiempos de COVID-19: Resumen de recomendaciones]]></article-title>
<source><![CDATA[Revista Colombiana Cir]]></source>
<year>2020</year>
<volume>35</volume>
<page-range>209-15</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fakhroddin]]></surname>
<given-names><![CDATA[BG]]></given-names>
</name>
<name>
<surname><![CDATA[Parviz]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Javad]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Hakimeh]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Ali]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sedative and Analgesic Effects of Propofol-Fentanyl Versus Propofol-Ketamine During Endoscopic Retrograde Cholangiopancreatography: A Double-Blind Randomized Clinical Trial]]></article-title>
<source><![CDATA[Anesth Pain Med]]></source>
<year>2016</year>
<volume>6</volume>
<numero>5</numero>
<issue>5</issue>
</nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Akhondzadeh]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Ghomeishi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Nesioonpour]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Nourizade]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A comparison between the effects of propofolefentanyl with propofoleketamine for sedation in patients undergoing endoscopic retrograde cholangiopancreatography outside the operating room]]></article-title>
<source><![CDATA[Biomedical journal]]></source>
<year>2016</year>
<volume>39</volume>
<numero>2016</numero>
<issue>2016</issue>
<page-range>145-9</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kayaalti]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Kayaalti]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Safety of applying midazolam-ketamine-propofol sedation combination under the supervision of endoscopy nurse with patient-controlled analgesia pump in colonoscopy]]></article-title>
<source><![CDATA[World J Clin Cases]]></source>
<year>2018</year>
<volume>6</volume>
<numero>16</numero>
<issue>16</issue>
<page-range>1146-54</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tian]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Luan]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Zhu]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Bao]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A randomized controlled trial for measuring effects on cognitive functions of adding ketamine to propofol during sedation for colonoscopy]]></article-title>
<source><![CDATA[Medicine]]></source>
<year>2020</year>
<volume>99</volume>
<numero>36</numero>
<issue>36</issue>
</nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Türkay]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Sebnem]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Oba]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Gokalp]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A comparison of different proportions of a ketaminepropofol mixture administered in a single injection for patients undergoing colonoscopy]]></article-title>
<source><![CDATA[Archivos de Medicina Scielo, June,]]></source>
<year>2015</year>
<volume>11</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>570-6</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
