<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1726-8958</journal-id>
<journal-title><![CDATA[Revista Médica La Paz]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Méd. La Paz]]></abbrev-journal-title>
<issn>1726-8958</issn>
<publisher>
<publisher-name><![CDATA[Colegio Médico de La Paz]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1726-89582021000200052</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[ENFERMEDAD DE PAGET VULVAR RECURRENTE CON RESPUESTA A QUIMIOTERAPIA CON CARBOPLATINO - PACLITAXEL. REPORTE DE UN CASO Y REVISIÓN DE LA LITERATURA]]></article-title>
<article-title xml:lang="en"><![CDATA[RECURRENT VULVAR PAGET DISEASE RESPONDING TO CARBOPLATIN-PACLITAXEL CHEMOTHERAPY. CASE REPORT AND LITERATURE REVIEW]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Medina Barrionuevo]]></surname>
<given-names><![CDATA[Rossio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Medina Pérez]]></surname>
<given-names><![CDATA[Luis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mamani Huanca]]></surname>
<given-names><![CDATA[Aldrin]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Conde Lia]]></surname>
<given-names><![CDATA[Fabian Hanss]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,HODE Oncológico de la Caja Nacional de Salud  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital de Clínicas Universitario  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af3">
<institution><![CDATA[,Caja Nacional de Salud HODE Oncológico ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af4">
<institution><![CDATA[,HODE Oncológico Emergencias ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<volume>27</volume>
<numero>2</numero>
<fpage>52</fpage>
<lpage>57</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_arttext&amp;pid=S1726-89582021000200052&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_abstract&amp;pid=S1726-89582021000200052&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_pdf&amp;pid=S1726-89582021000200052&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La enfermedad de Paget vulvar es sumamente rara, representa menos del 1% de las neoplasias vulvares. Generalmente tiene un curso crónico y es altamente recurrente. La cirugía es el estándar de tratamiento; sin embargo, los decepcionantes resultados del tratamiento quirúrgico y la alta morbilidad, han llevado a buscar otras alternativas de tratamiento incluyendo radioterapia, vaporizaciones con láser de CO2 y quimioterapia entre otros. Todas ellas con resultados prometedores, aunque hay una necesidad de estudios prospectivos para explorar estos enfoques. Presentamos el caso de una paciente con enfermedad de Paget vulvar recurrente con muy buena respuesta a la quimioterapia sistémica con carboplatino mas paclitaxel.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Vulvar Paget&#8217;s disease is extremely rare, accounting for less than 1% of the vulvar neoplasia. Usually it has a chronic course and is highly recurrent. Surgery is the standard treatment; however, the disappointing results of surgical treatment and high morbidity, have led to seek alternative treatment including radiotherapy, sprays CO2 laser and chemotherapy among others. All with promising results, though there is a need for prospective studies to explore these approaches. We report the case of a patient with vulvar Paget&#8217;s disease recurrent with very good response to systemic chemotherapy with carboplatin plus paclitaxel.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Enfermedad de Paget vulvar]]></kwd>
<kwd lng="es"><![CDATA[tratamiento multimodal]]></kwd>
<kwd lng="en"><![CDATA[vulvar Paget disease]]></kwd>
<kwd lng="en"><![CDATA[multimodal treatment]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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