<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1652-6776</journal-id>
<journal-title><![CDATA[Cuadernos Hospital de Clínicas]]></journal-title>
<abbrev-journal-title><![CDATA[Cuad. - Hosp. Clín.]]></abbrev-journal-title>
<issn>1652-6776</issn>
<publisher>
<publisher-name><![CDATA[Universidad Mayor de San Andrés, Facultad de Medicina]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1652-67762025000100011</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[VALOR PREDICTIVO POSITIVO DE LA PROCALCITONINA SÉRICA COMO MARCADOR DE INFECCIÓN VESICULAR E INICIO DE TRATAMIENTO ANTIBIÓTICO EN PACIENTES CON COLECISTITIS AGUDA LITIÁSICA.]]></article-title>
<article-title xml:lang="en"><![CDATA[POSITIVE PREDICTIVE VALUE OF SERUM PROCALCITONIN AS A MARKER OF GALLBLADDER INFECTION AND INITIATION OF ANTIBIOTIC TREATMENT IN PATIENTS WITH ACUTE LITHIASIC CHOLECYSTITIS.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Claros]]></surname>
<given-names><![CDATA[BN]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pinilla]]></surname>
<given-names><![CDATA[LR]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodrigo]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Manterola]]></surname>
<given-names><![CDATA[DC]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Claros]]></surname>
<given-names><![CDATA[BN]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pinilla]]></surname>
<given-names><![CDATA[LR]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodrigo]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Manterola]]></surname>
<given-names><![CDATA[DC]]></given-names>
</name>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,aff1  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,aff2  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af3">
<institution><![CDATA[,aff3  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<volume>66</volume>
<numero>1</numero>
<fpage>11</fpage>
<lpage>18</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_arttext&amp;pid=S1652-67762025000100011&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_abstract&amp;pid=S1652-67762025000100011&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_pdf&amp;pid=S1652-67762025000100011&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN INTRODUCCION: El uso de antibióticos de manera rutinaria en colecistitis aguda (CA) es controversial. OBJETIVO: Determinar el valor predictivo positivo (VPP) de la procalcitonina sérica como marcador de infección de la vesícula biliar en el curso de una CA. METODOLOGÍA DE LA INVESTIGACIÓN: Test Diagnóstico RESULTADOS: Se incluyeron 147 pacientes con un promedio de edad de 46,7 años, divididos en 73 del género femenino (49,7%) y 74 del masculino (50,3%). En el cuadro clínico 128 pacientes (87,1%) presentaron singo de Murphy positivo y 127 (86,4%) contractura muscular. El promedio del grosor de la pared vesicular en la ultrasonografía fue de 5,6 mm. Presencia de líquido peri vesicular en 8 pacientes (5,4%). El recuento leucocitario con un promedio de 8656 glóbulos blancos por mm3, y un recuento neutrofílico porcentual de 74,9. La dosificación de promedio de PCT fue de 0,23(0,2 ng/ml. El tiempo quirúrgico promedio en minutos fue de 50 min. En 57 pacientes (38,8%) hubo derrame accidental o punción premeditada de la vesícula biliar. El porcentaje de conversión a cirugía abierta en 3 pacientes (2%). Se describen 24 pacientes con cultivo positivo de bilis (16,32%). La sensibilidad calculada para la calcitonina como marcador de infección bacteriana en la vesícula biliar fue de 25% y una especificad del 74%. Los valores predictivos positivo y negativos fueron de 46% y 53% respectivamente, con razones de verosimilitud positiva y negativa de 0,96 y 1,01 respectivamente. CONCLUSION: El valor predictivo positivo de la PCT como indicador de infección de la vesícula biliar durante un cuadro de CA es solo del 46%.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT INTRODUCTION: The routine use of antibiotic in acute cholecystitis (AC) is controversial. OBJETIVE: To determine the positive predictive value (PPV) of serum procalcitonin as a marker of gallbladder infection in an acute cholecystitis (AC). RESEARCH METHODOLOGY: Diagnostic Test RESULTS: 147 patients were included with an average age of 46.7 years, divided into 73 female (49.7%) and 74 male (50.3%). In the clinical picture, 128 patients (87.1%) presented positive Murphy's sign and 127 (86.4%) presented muscle contracture. The average gallbladder wall thickness on ultrasonography was 5.6 mm. Presence of perivesicular fluid in 8 patients (5.4%). The leukocyte counts averaged 8656 white blood cells per mm3, and a percentage neutrophil count of 74.9. The average dosage of PCT was 0.23(0.2 ng/ml. The average surgical time in minutes was 50. In 57 patients (38.8%) there was accidental spillage or premeditated puncture of the gallbladder. The percentage of conversion to open surgery in 3 patients (2%). 24 patients with positive bile culture were described (16.32%). The calculated sensitivity for calcitonin as a marker of bacterial infection in the gallbladder was 25% and a specificity of 74%. The positive and negative predictive values &#8203;&#8203;were 46% and 53% respectively, with positive and negative likelihood ratios of 0.96 and 1.01 respectively. CONCLUSION: The positive predictive value of PCT as an indicator of gallbladder infection during CA is only 46%.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Procalcitonina]]></kwd>
<kwd lng="es"><![CDATA[infección vesicular]]></kwd>
<kwd lng="es"><![CDATA[colecistitis Aguda]]></kwd>
<kwd lng="en"><![CDATA[Procalcitonin]]></kwd>
<kwd lng="en"><![CDATA[gallbladder infection]]></kwd>
<kwd lng="en"><![CDATA[acute cholecystitis]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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