<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2075-6194</journal-id>
<journal-title><![CDATA[Revista de Investigacion e Informacion en Salud]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Inv. Inf. Sal.]]></abbrev-journal-title>
<issn>2075-6194</issn>
<publisher>
<publisher-name><![CDATA[Universidad Privada del Valle]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2075-61942023000200095</article-id>
<article-id pub-id-type="doi">10.52428/20756208.v18i45.977</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Manejo fisioterapéutico de un paciente con esclerosis lateral amiotrófica]]></article-title>
<article-title xml:lang="en"><![CDATA[Physiotherapeutic management of a patient with amyotrophic lateral sclerosis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Perez-Chuquimia]]></surname>
<given-names><![CDATA[Marcos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,aff1  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<volume>19</volume>
<numero>45</numero>
<fpage>95</fpage>
<lpage>101</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_arttext&amp;pid=S2075-61942023000200095&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_abstract&amp;pid=S2075-61942023000200095&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_pdf&amp;pid=S2075-61942023000200095&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La esclerosis lateral amiotrófica es una de las enfermedades más comunes en nuestro medio, y asimismo de las más trágicas para los pacientes que la padecen, para su entorno familiar y social. Esta no muestra una etiología clara, pese a su origen desconocido, la prevalencia a nivel mundial es alta, variando entre 2 y 11 casos por 100 000 personas; la edad de presentación es de 58 a 63 años en los menos frecuentes, y 47 a 52 años para los casos más comunes, en la mayoría de los casos en el sexo masculino. Para el diagnóstico es esencial una evaluación clínica correcta, con refuerzo y apoyo de estudios complementarios neurofisiológicos, la característica fundamental es el deterioro neuronal, en miembros inferiores y superiores, además debilidad en la musculatura bulbar, y algunos casos presentan deterioro cognitivo frontotemporal; otros estudios se apoyan en la electromiografía. No existe tratamiento médico definitivo, sin embargo, ante la clínica complicada de la patología, es útil el uso de medidas de soporte sobre todo con apoyo ventilatorio y nutricional, pero sobre todo fisioterapia en el sistema musculoesquelético, que se describe a continuación y es para prevenir la atrofia muscular en músculos no afectados, y rigidez articular por ausencia periódica del movimiento voluntario.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Amyotrophic lateral sclerosis is one of the most common diseases in our environment, and also one of the most tragic for the patients who suffer from it, and for their family and social environment. This does not show a clear etiology, despite its unknown origin, the prevalence worldwide is high, varying between 2 and 11 cases per 100 000 people; The age of presentation is 58 to 63 years in the less frequent cases, and 47 to 52 years for the most common cases, in most cases in males. For the diagnosis, a correct clinical evaluation is essential, with reinforcement and support from complementary neurophysiological studies. The fundamental characteristic is neuronal deterioration in the lower and upper limbs, as well as weakness in the bulbar muscles, and some cases present frontotemporal cognitive impairment; Other studies are based on electromyography. There is no definitive medical treatment, however, in the face of complicated symptoms of the pathology, the use of support measures is useful, especially with ventilatory and nutritional support, but above all physiotherapy in the musculoskeletal system, which is described below and is for prevent muscle atrophy in unaffected muscles, and joint stiffness due to periodic absence of voluntary movement.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Esclerosis lateral amiotrófica]]></kwd>
<kwd lng="es"><![CDATA[Apoyo en el sistema musculoesquelético]]></kwd>
<kwd lng="es"><![CDATA[debilidad en la musculatura bulbar]]></kwd>
<kwd lng="en"><![CDATA[Amyotrophic lateral sclerosis]]></kwd>
<kwd lng="en"><![CDATA[Support in the musculoskeletal system]]></kwd>
<kwd lng="en"><![CDATA[weakness in the bulbar muscles]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hardiman]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[van den Berg]]></surname>
<given-names><![CDATA[LH]]></given-names>
</name>
<name>
<surname><![CDATA[Kiernan]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical diagnosis and management of amyotrophic lateral sclerosis]]></article-title>
<source><![CDATA[Nat Rev Neurol]]></source>
<year></year>
<volume>7</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>639-49</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Andersen]]></surname>
<given-names><![CDATA[PM]]></given-names>
</name>
<name>
<surname><![CDATA[Al-Chalabi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical genetics of amyotrophic lateral sclerosis: what do we really know?]]></article-title>
<source><![CDATA[Nat Rev Neurol]]></source>
<year></year>
<volume>7</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>603-15</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ravits]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[La Spada]]></surname>
<given-names><![CDATA[AR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[ALS motor phenotype heterogeneity, focality, and spread: deconstructing motor neuron degeneration]]></article-title>
<source><![CDATA[Neurology]]></source>
<year></year>
<volume>73</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>805-11</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[D&#8217;Amico]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Factor-Litvak]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Santella]]></surname>
<given-names><![CDATA[RM]]></given-names>
</name>
<name>
<surname><![CDATA[Mitsumoto]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis]]></article-title>
<source><![CDATA[Free Radic Biol Med]]></source>
<year></year>
<numero>65</numero>
<issue>65</issue>
<page-range>509-27</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Spreux-Varoquaux]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Bensimon]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Lacomblez]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Salachas]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Pradat]]></surname>
<given-names><![CDATA[PF]]></given-names>
</name>
<name>
<surname><![CDATA[Le Forestier]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Glutamate levels in cerebrospinal fluid in amyotrophic lateral sclerosis: a reappraisal using a new HPLC method with coulometric detection in a large cohort of patients]]></article-title>
<source><![CDATA[J Neurol Sci]]></source>
<year></year>
<volume>193</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>73-8</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Menzies]]></surname>
<given-names><![CDATA[FM]]></given-names>
</name>
<name>
<surname><![CDATA[Ince]]></surname>
<given-names><![CDATA[PG]]></given-names>
</name>
<name>
<surname><![CDATA[Shaw]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mitochondrial involvement in amyotrophic lateral sclerosis]]></article-title>
<source><![CDATA[Neurochem Int]]></source>
<year></year>
<volume>40</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>543-51</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tomkins]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Usher]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Slade]]></surname>
<given-names><![CDATA[JY]]></given-names>
</name>
<name>
<surname><![CDATA[Ince]]></surname>
<given-names><![CDATA[PG]]></given-names>
</name>
<name>
<surname><![CDATA[Curtis]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Bushby]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Novel insertion in the KSP region of the neurofilament heavy gene in amyotrophic lateral sclerosis (ALS)]]></article-title>
<source><![CDATA[Neuroreport]]></source>
<year></year>
<volume>9</volume>
<numero>17</numero>
<issue>17</issue>
<page-range>3967-70</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Julien]]></surname>
<given-names><![CDATA[JP]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[ALS: astrocytes move in as deadly neighbors]]></article-title>
<source><![CDATA[Nat Neurosci]]></source>
<year></year>
<volume>10</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>535-7</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sathasivam]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Ince]]></surname>
<given-names><![CDATA[PG]]></given-names>
</name>
<name>
<surname><![CDATA[Shaw]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Apoptosis in amyotrophic lateral sclerosis: a review of the evidence]]></article-title>
<source><![CDATA[Neuropathol Appl Neurobiol]]></source>
<year></year>
<volume>27</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>257-74</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shaw]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Molecular and cellular pathways of neurodegeneration in motor neurone disease]]></article-title>
<source><![CDATA[J Neurol Neurosurg Psychiatry]]></source>
<year></year>
<volume>76</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>1046-57</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="">
<source><![CDATA[ELA una enfermedad sin cura y progresiva]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pringle]]></surname>
<given-names><![CDATA[CE]]></given-names>
</name>
<name>
<surname><![CDATA[Hudson]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
<name>
<surname><![CDATA[Munoz]]></surname>
<given-names><![CDATA[DG]]></given-names>
</name>
<name>
<surname><![CDATA[Kiernan]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Brown]]></surname>
<given-names><![CDATA[WF]]></given-names>
</name>
<name>
<surname><![CDATA[Ebers]]></surname>
<given-names><![CDATA[GC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Primary lateral sclerosis. Clinical features, neuropathology and diagnostic criteria]]></article-title>
<source><![CDATA[Brain]]></source>
<year></year>
<volume>115</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>495-520</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ruiz Martinez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[García García]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
</person-group>
<source><![CDATA[Fisiopatología de la esclerosis lateral amiotrófica. Trabajo de fin de grado]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Perez Akli]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Schiava]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Melcom]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Estudio epidemiológico multicéntrico sobre esclerosis lateral amiotrófica en la Ciudad de Buenos Aires]]></article-title>
<source><![CDATA[Neurol arg]]></source>
<year></year>
<volume>9</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>225-30</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lascurain Vázquez]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<source><![CDATA[Esclerosis lateral amiotrófica (ELA) Enfermedad, tratamiento actual y nuevas estrategias terapéuticas; trabajo de fin de grado]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Seco Calvo]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Sistema Nervioso, Métodos, Fisioterapia Clínica, y Afecciones para Fisioterapeutas]]></source>
<year></year>
<publisher-name><![CDATA[Editorial Medica Panamericana S.A]]></publisher-name>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
