<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1012-2966</journal-id>
<journal-title><![CDATA[Gaceta Médica Boliviana]]></journal-title>
<abbrev-journal-title><![CDATA[Gac Med Bol]]></abbrev-journal-title>
<issn>1012-2966</issn>
<publisher>
<publisher-name><![CDATA[Facultad de Medicina de la Universidad Mayor de San Simón]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1012-29662025000200182</article-id>
<article-id pub-id-type="doi">10.47993/gmb.v48i2.1027</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Los polimorfismos del gen IL28B no se asocian con el riesgo de infección por HTLV-1: un metaanálisis]]></article-title>
<article-title xml:lang="en"><![CDATA[IL28B gene polymorphisms are not associated with the risk of HTLV-1 infection: A Meta-Analysis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quiroz-Ruiz]]></surname>
<given-names><![CDATA[Hans Ramón]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Miranda-Ulloa]]></surname>
<given-names><![CDATA[Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[León-Torres]]></surname>
<given-names><![CDATA[Carlos Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bardales-Vásquez]]></surname>
<given-names><![CDATA[Cecilia Betzabet]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Trujillo Escuela de Posgrado ]]></institution>
<addr-line><![CDATA[Trujillo ]]></addr-line>
<country>Peru</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Nacional de Salud Centro Nacional de Salud Pública Laboratorio de Referencia Nacional de Virus de Transmisión Sexual]]></institution>
<addr-line><![CDATA[Lima ]]></addr-line>
<country>Perú</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Nacional de Trujillo Facultad de Ciencias Biológicas ]]></institution>
<addr-line><![CDATA[Trujillo ]]></addr-line>
<country>Peru</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Privada Antenor Orrego Facultad de Medicina Humana ]]></institution>
<addr-line><![CDATA[Trujillo ]]></addr-line>
<country>Peru</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<volume>48</volume>
<numero>2</numero>
<fpage>182</fpage>
<lpage>189</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_arttext&amp;pid=S1012-29662025000200182&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_abstract&amp;pid=S1012-29662025000200182&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_pdf&amp;pid=S1012-29662025000200182&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La búsqueda de factores genéticos de riesgo es importante para comprender la susceptibilidad al  Virus Linfotrópico TTipo 1 Humano (HTLV-1), aunque los polimorfismos del gen IL28B se han asociado con el riesgo de infección en otros virus, su papel en el riesgo de infección por HTLV-1 permanece incierto.  Objetivo:  determinar si los Polimorfismos de un Solo Nucleótido (SNP) rs8099917 y rs12979860 del gen IL28B están asociados con el riesgo de infección HTLV-1.  Material y métodos:  se realizó un metaanálisis de estudios de casos y controles, se efectúo una búsqueda en Pubmed, Google Scholar y Scopus. Se extrajeron frecuencias genotípicas de los polimorfismos. Mediante un metaanálisis de asociación genética empleando el programa Metagenyo, se estimaron Odds Ratios (OR) e intervalos de confianza al 95% para cuatro modelos genéticos.  Resultados:  Se incluyeron cuatro estudios, constituyendo 875 participantes para el rs12979860 y 718 para rs8099917. No se observó desviación del equilibrio Hardy-Weinberg (p&gt;0,05). No se evidenció asociación estadísticamente significativa de rs12979860 con riesgo de infección por HTLV-1 (modelo alélico: OR= 0,98; p= 0,89; modelo recesivo: OR= 1,03; p=0,85; modelo dominante: OR= 0,91; p= 0,63; modelo sobredominante OR= 0,92; p= 0,59); ni del rs8099917 (modelo alélico: OR= 1,01; p=0,97; modelo recesivo: OR= 0,95; p=0,78; modelo dominante: OR= 1,09; p=0,80; modelo sobredominante: OR= 1,12; p=0,53).  Conclusión:  El metaanálisis muestra que los SNPs rs8099917 y rs12979860, no están asociados con el riesgo de infección por HTLV-1. Se resaltan la necesidad de más investigaciones de tipo caso-control que permitan contrastar nuestra conclusión.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The investigation of genetic risk factors is important for understanding susceptibility to Human T-Cell  Lymphotropic Virus Type 1 (HTLV-1). Although IL28B gene polymorphisms have been implicated in infection risk for other viruses, their role in HTLV-1 infection risk remains uncertain.  Objective:  to determine whether the Single Nucleotide Polymorphisms (SNPs) rs8099917 and rs12979860 in the IL28B gene are associated with the risk of HTLV-1 infection.  Material and Methods:  a meta-analysis of case-control studies was performed. A search was conducted in PubMed, Google Scholar, and Scopus. Genotypic frequencies of the polymorphisms were extracted. Using a genetic association meta-analysis with the Metagenyo software, Odds Ratios (OR) and 95% confidence intervals were estimated for four genetic models.  Results:  four studies were included, comprising 875 participants for rs12979860 and 718 for rs8099917. No deviation from Hardy-Weinberg equilibrium was observed (p&gt;0.05). No statistically significant association was found between rs12979860 and HTLV-1 infection risk (allelic model: OR= 0.98; p= 0.89; recessive model: OR= 1.03; p=0.85; dominant model: OR= 0.91; p= 0.63; overdominant model: OR= 0.92; p= 0.59), nor for rs8099917 (allelic model: OR= 1.01; p=0.97; recessive model: OR= 0.95; p=0.78; dominant model: OR= 1.09; p=0.80; overdominant model: OR= 1.12; p=0.53).  Conclusion:  This meta-analysis indicates that the SNPs rs8099917 and rs12979860 are not associated with the risk of HTLV-1 infection. This underscores the need for further case-control studies to validate our findings.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[interleucinas]]></kwd>
<kwd lng="es"><![CDATA[metaanálisis]]></kwd>
<kwd lng="es"><![CDATA[polimorfismo de nucleótido simple]]></kwd>
<kwd lng="es"><![CDATA[Virus Linfotrópico T Humano tipo 1]]></kwd>
<kwd lng="en"><![CDATA[interleukins]]></kwd>
<kwd lng="en"><![CDATA[meta-analysis]]></kwd>
<kwd lng="en"><![CDATA[polymorphism single nucleotide]]></kwd>
<kwd lng="en"><![CDATA[Human T-lymphotropic virus 1]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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