<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1012-2966</journal-id>
<journal-title><![CDATA[Gaceta Médica Boliviana]]></journal-title>
<abbrev-journal-title><![CDATA[Gac Med Bol]]></abbrev-journal-title>
<issn>1012-2966</issn>
<publisher>
<publisher-name><![CDATA[Facultad de Medicina de la Universidad Mayor de San Simón]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1012-29662025000200162</article-id>
<article-id pub-id-type="doi">10.47993/gmb.v48i2.1003</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Asociación entre infección por Helicobacter Pylori y anemia ferropenica: una revisión sistemática]]></article-title>
<article-title xml:lang="en"><![CDATA[Association between Helicobacter Pylori infection and iron deficiency anemia: a systematic review]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carpio-Ccencho]]></surname>
<given-names><![CDATA[Johny Angel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guzmán-Calcina]]></surname>
<given-names><![CDATA[Carmen Sandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Ricardo Palma Facultad de Medicina Humana ]]></institution>
<addr-line><![CDATA[Lima ]]></addr-line>
<country>Peru</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Ricardo Palma Facultad de Medicina Humana Instituto de Investigaciones Biomédicas - INICIB]]></institution>
<addr-line><![CDATA[Lima ]]></addr-line>
<country>Peru</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<volume>48</volume>
<numero>2</numero>
<fpage>162</fpage>
<lpage>167</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_arttext&amp;pid=S1012-29662025000200162&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_abstract&amp;pid=S1012-29662025000200162&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_pdf&amp;pid=S1012-29662025000200162&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objetivos:  la anemia ferropénica es una enfermedad muy frecuente que afecta a una gran parte de la población; sin embargo, hasta la actualidad no se han identificado con exactitud los factores asociados a su aparición.  Métodos:  para investigar el vínculo entre la Anemia Ferropénica y la infección por Helicobacter pylori, se analizaron estudios observacionales mediante una revisión sistemática y metaanálisis. La selección de estudios se realizó a partir de las bases de datos Pubmed, SCOPUS y EMBASE. La infección se identificó a través de múltiples métodos diagnósticos (prueba de aliento con urea, prueba de anticuerpos de inmunoglobulina, prueba de antígeno en heces, endoscopia), y la anemia se definió por concentraciones bajas de hemoglobina. La síntesis cuantitativa de los datos, usando un modelo de aleatorización, generó Odds Ratios (OR) como medida de asociación, mientras que la heterogeneidad de los hallazgos se valoró con la prueba de I cuadrado.  Resultados:  la síntesis de los siete estudios seleccionados demostró una asociación entre las dos variables, con una razón de probabilidades OR de 2,20 (IC 95%: 1,21-3,99). Por otro lado, el grado de heterogeneidad detectado entre los efectos de los distintos estudios se clasificó como moderado a alto.  Conclusiones:  la asociación entre Helicobacter pylori y la anemia ferropénica fue estadísticamente significativa en la mayoría de los trabajos revisados. No obstante, los autores coinciden en que el reducido número de investigaciones sobre el tema hace imperiosa la realización de nuevos estudios que permitan profundizar en este hallazgo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Objectives:  iron deficiency anemia is a very common disease that affects a large part of the population; however, to date the factors associated with its appearance have not been accurately identified.  Methods:  To investigate the association between iron deficiency anemia and Helicobacter pylori infection, observational studies were analyzed through a systematic review and meta-analysis. The selection of studies was made from the Pubmed, SCOPUS and EMBASE databases. Infection was identified through multiple diagnostic methods (urea breath test, immunoglobulin antibody test, stool antigen test, endoscopy), and anemia was defined by low hemoglobin concentrations. The quantitative synthesis of the data, using a randomization model, generated Odds Ratios (OR) as a measure of association, while the heterogeneity of the findings was assessed with the I-square test.  Results:  The synthesis of the seven selected studies demonstrated an association between the two variables, with an OR odds ratio of 2.20 (95% CI: 1,21-3,99). On the other hand, the degree of heterogeneity detected between the effects of the different studies was classified as moderate to high.  Conclusions:  The association between Helicobacter pylori and iron deficiency anemia was statistically significant in most of the studies reviewed. However, the authors agree that the small number of studies on the subject makes it imperative to carry out new studies to deepen this finding.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[anemia por deficiencia de hierro]]></kwd>
<kwd lng="es"><![CDATA[hemoglobina]]></kwd>
<kwd lng="es"><![CDATA[Helicobacter pylori]]></kwd>
<kwd lng="en"><![CDATA[Iron-deficiency Anemia]]></kwd>
<kwd lng="en"><![CDATA[hemoglobin]]></kwd>
<kwd lng="en"><![CDATA[Helicobacter pylori]]></kwd>
</kwd-group>
</article-meta>
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<numero>3</numero>
<issue>3</issue>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
