<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1012-2966</journal-id>
<journal-title><![CDATA[Gaceta Médica Boliviana]]></journal-title>
<abbrev-journal-title><![CDATA[Gac Med Bol]]></abbrev-journal-title>
<issn>1012-2966</issn>
<publisher>
<publisher-name><![CDATA[Facultad de Medicina de la Universidad Mayor de San Simón]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1012-29662025000200087</article-id>
<article-id pub-id-type="doi">10.47993/gmb.v48i2.1114</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Efecto de COVID-19 en el diagnóstico de Chagas congénito en tres departamentos de Bolivia]]></article-title>
<article-title xml:lang="en"><![CDATA[Effect of COVID-19 on the diagnosis of congenital Chagas disease in three departments of Bolivia]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Olguín]]></surname>
<given-names><![CDATA[Beatriz Amparo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tinajeros G.]]></surname>
<given-names><![CDATA[Freddy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mercado-Saavedra]]></surname>
<given-names><![CDATA[Brandon N.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Autónoma Gabriel René Moreno  ]]></institution>
<addr-line><![CDATA[Santa Cruz ]]></addr-line>
<country>Bolivia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Asociación Benéfica PRISMA  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Bolivia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Católica Boliviana San Pablo Instituto de Investigación de Medicina ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Bolivia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<volume>48</volume>
<numero>2</numero>
<fpage>87</fpage>
<lpage>94</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_arttext&amp;pid=S1012-29662025000200087&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_abstract&amp;pid=S1012-29662025000200087&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_pdf&amp;pid=S1012-29662025000200087&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objetivo:  evaluar el impacto de la COVID-19 en el tamizaje y la cobertura diagnóstica de la enfermedad de Chagas en mujeres gestantes y recién nacidos (RN) en tres departamentos de Bolivia.  Material y métodos:  estudio cuantitativo, observacional y retrospectivo, de series temporales (unidad mensual, 2018-2022), con comparación prepandemia, pandemia y pospandemia. Se usaron fuentes programáticas departamentales; análisis descriptivo y regresión logística de la "brecha de control&#8221; neonatal.  Resultados:  el tamizaje disminuyó en gestantes y RN en los tres departamentos. Santa Cruz: gestantes 78 966, 68 338 y 45 266; RN 9 666, 8 720 y 4 182. Cochabamba: gestantes 138 175, 106 785 y 58 946; RN 5 482, 3 892 y 1 640. Chuquisaca: gestantes 35 779, 30 597 y 14 414; RN 4 303, 2 836 y 1 246. La positividad materna descendió: Santa Cruz 15,2%, 13,6% y 10,8%; Cochabamba 9,9%, 8,31% y 7,1%; Chuquisaca 21,1%, 16,9% y 14,1%. La transmisión vertical registrada permaneció &lt;3% en los tres contextos. La brecha de control neonatal fue heterogénea: en Santa Cruz se redujo de prepandemia a pandemia y aumentó en pospandemia (OR 2,6; p&lt;0,001); en Cochabamba no hubo cambios significativos; en Chuquisaca se observó un patrón mixto (prepandemia a pandemia OR 1,09; pandemia a pospandemia OR 0,83; p&lt;0,001).  Conclusiones:  la COVID-19 contrajo la cobertura de tamizaje materno-infantil de forma heterogénea, con brechas pospandemia persistentes. Las bajas tasas de transmisión vertical probablemente reflejan subdiagnóstico. Urge recuperar cobertura, fortalecer la vigilancia y optimizar el algoritmo diagnóstico neonatal.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Objective:  To assess the impact of COVID-19 on screening and diagnostic coverage for Chagas disease among pregnant women and newborns in three Bolivian departments.  Material and methods:  Quantitative, observational, retrospective time-series study (monthly unit, 2018-2022) comparing pre-pandemic, pandemic, and post-pandemic periods. Departmental program data; descriptive analyses and logistic regression of the neonatal "control gap&#8221;  Results:  Screening decreased for both pregnant women and newborns across all departments. Santa Cruz: pregnant women 78 966, 68 338, and 45 266; newborns 9 666, 8 720, and 4 182. Cochabamba: pregnant women 138 175, 106 785, and 58 946; newborns 5 482, 3 892, and 1 640. Chuquisaca: pregnant women 35 779, 30 597, and 14 414; newborns 4 303, 2 836, and 1 246. Maternal positivity declined: Santa Cruz 15,2%, 13,6%, and 10,8%; Cochabamba 9,9%, 8,31%, and 7,1%; Chuquisaca 21,1%, 16,9%, and 14,1%. Recorded vertical transmission remained below 3% across settings. The neonatal control gap was heterogeneous: Santa Cruz narrowed from pre-pandemic to pandemic and increased post-pandemic (OR 2,6; p&lt;0,001); Cochabamba showed no significant changes; Chuquisaca showed a mixed pattern (pre-pandemic to pandemic OR 1,09; pandemic to post-pandemic OR 0,83; p&lt;0,001).  Conclusions:  COVID-19 markedly contracted maternal- infant Chagas screening coverage with heterogeneous departmental effects and persistent post-pandemic gaps. Low apparent vertical transmission likely reflects under-diagnosis. Recovery of coverage, strengthened surveillance, and improvements to neonatal diagnostic algorithms are urgently needed.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[COVID-19]]></kwd>
<kwd lng="es"><![CDATA[enfermedad de Chagas]]></kwd>
<kwd lng="es"><![CDATA[mujeres embarazadas]]></kwd>
<kwd lng="es"><![CDATA[recién nacido]]></kwd>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[Chagas disease]]></kwd>
<kwd lng="en"><![CDATA[pregnant women]]></kwd>
<kwd lng="en"><![CDATA[newborn]]></kwd>
</kwd-group>
</article-meta>
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