<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1012-2966</journal-id>
<journal-title><![CDATA[Gaceta Médica Boliviana]]></journal-title>
<abbrev-journal-title><![CDATA[Gac Med Bol]]></abbrev-journal-title>
<issn>1012-2966</issn>
<publisher>
<publisher-name><![CDATA[Facultad de Medicina de la Universidad Mayor de San Simón]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1012-29662025000200070</article-id>
<article-id pub-id-type="doi">10.47993/gmb.v48i2.1038</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Salinomicina comercial tiene actividad antiproliferativa sobre tres líneas celulares de cáncer en hipoxia natural a 3 600 msnm]]></article-title>
<article-title xml:lang="en"><![CDATA[Commercial salinomycin exhibits antiproliferative activity on three cancer cell lines under natural hypoxic conditions at 3 600 masl]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodrigo Lira]]></surname>
<given-names><![CDATA[Gloria del Carmen]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Iturri-Soliz]]></surname>
<given-names><![CDATA[J. Pablo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rollano-Peñaloza]]></surname>
<given-names><![CDATA[Oscar M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Mayor de San Andrés  ]]></institution>
<addr-line><![CDATA[La Paz ]]></addr-line>
<country>Bolivia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Mayor Real y Pontificia de San Francisco Xavier de Chuquisaca  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Bolivia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<volume>48</volume>
<numero>2</numero>
<fpage>70</fpage>
<lpage>78</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_arttext&amp;pid=S1012-29662025000200070&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_abstract&amp;pid=S1012-29662025000200070&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_pdf&amp;pid=S1012-29662025000200070&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La salinomicina es un compuesto prometedor como medicamento contra el cáncer debido a su acción antiproliferativa contra células madre de cáncer y su acción selectiva, es decir que no ataca células normales. Se ha mostrado resultados prometedores sobre la versión ultrapura del compuesto, pero aún no se ha evaluado la versión comercial, que actualmente es utilizada como suplemento alimenticio por veterinarios.  Objetivo:  determinar la actividad antiproliferativa de la versión ultrapura y comercial de salinomicina sobre tres líneas celulares de cáncer.  Métodos:  se realizó un estudio experimental in vitro transversal donde se evaluó el efecto antiproliferativo de dos versiones de salinomicina sobre las líneas Hela (células de cáncer cervicouterino), A549 (células de cáncer de pulmón) y MCF-7 (células de cáncer de mama) mediante el ensayo de citotoxicidad MTT y la evaluación de morfología celular apoptótica a las 48h y 72h de tratamiento. Además se evaluó las cantidades de salinomicina asimiladas por las líneas celulares a una altitud de 3 600 msnm.  Resultados:  salinomicina en su versión comercial tiene una buena actividad antiproliferativa contra las líneas celulares HeLa, A549 y MCF-7. Ésta actividad es similar a la actividad del compuesto ultrapuro y al reportado por articulos previamente publicados. La asimilación de la salinomicina por las líneas celulares fue bastante baja, observandose que dentro de 72 horas de incubación todavia se observaba el 75% del compuesto en las concentraciones más altas. Los resultados sugieren que la versión comercial de salinomicina tiene el potencial de convertirse en una droga de bajo costo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Salinomycin is a promising compound as an anticancer drug due to its antiproliferative action against cancer stem cells and its selective action, meaning it does not attack normal cells. Promising results have been shown for the ultrapure version of the compound, but the commercial version, which is currently used as a dietary supplement by veterinarians, has not yet been evaluated.  Objective:  to determine the antiproliferative activity of the ultrapure version and the commercial version of salinomycin on three cancer cell lines.  Methods:  a transversal in vitro experimental study was deployed to assess the antiproliferative effect of two versions of salinomycin on cancer cell lines Hela (cervical cancer cells), A549 (lung cancer cells), and MCF-7 (breast cancer cells). The MTT cytotoxicity assay was applied and the apoptotic cell morphology at 48h and 72h of treatment was evaluated. In addition, the amounts of salinomycin assimilated by the cell lines were measured at an altitude of 3 600 meters above sea level.  Results:  The results reveal that salinomycin in its commercial version has a good antiproliferative activity against cell lines of breast cancer (MCF-7), cervical cancer (HeLa) and lung cancer (A549), this activity is similar to the activity of the ultrapure compound and to that reported by published articles. The assimilation of salinomycin by the cell lines was quite low, observing that within 72 hours of incubation at the highest concentrations, 75% of the compound still remained. The results suggest that salinomycin in its commercial version, has the potential to become a low-cost drug.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[agentes antineoplásicos]]></kwd>
<kwd lng="es"><![CDATA[neoplasias del cuello uterino]]></kwd>
<kwd lng="es"><![CDATA[neoplasias de la mama]]></kwd>
<kwd lng="es"><![CDATA[neoplasias pulmonares]]></kwd>
<kwd lng="es"><![CDATA[salinomicina]]></kwd>
<kwd lng="en"><![CDATA[antineoplastic agents]]></kwd>
<kwd lng="en"><![CDATA[uterine cervical neoplasms]]></kwd>
<kwd lng="en"><![CDATA[breast neoplasms]]></kwd>
<kwd lng="en"><![CDATA[lung neoplasms]]></kwd>
<kwd lng="en"><![CDATA[salinomycin]]></kwd>
</kwd-group>
</article-meta>
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