<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1012-2966</journal-id>
<journal-title><![CDATA[Gaceta Médica Boliviana]]></journal-title>
<abbrev-journal-title><![CDATA[Gac Med Bol]]></abbrev-journal-title>
<issn>1012-2966</issn>
<publisher>
<publisher-name><![CDATA[Facultad de Medicina de la Universidad Mayor de San Simón]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1012-29662021000200225</article-id>
<article-id pub-id-type="doi">10.47993/gmb.v44i2.285</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Uso de Quinolonas como Factor de Riesgo para Infección Oportunista Severa por Cándida en Pacientes Adultos Críticamente Enfermos]]></article-title>
<article-title xml:lang="en"><![CDATA[Quinolone use as a Risk Factor for Severe Opportunistic Candida Infection in Critically Ill Adult Patients]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Moreno]]></surname>
<given-names><![CDATA[Javier Mauricio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Burbano]]></surname>
<given-names><![CDATA[Adriana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Pedagógica y Tecnológica de Colombia Facultad de Ciencias de la Salud Escuela de Medicina]]></institution>
<addr-line><![CDATA[Tunja Boyacá]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Pedagógica y Tecnológica de Colombia Facultad de Ciencias de la Salud Escuela de Medicina]]></institution>
<addr-line><![CDATA[Tunja Boyacá]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<volume>44</volume>
<numero>2</numero>
<fpage>225</fpage>
<lpage>232</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_arttext&amp;pid=S1012-29662021000200225&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_abstract&amp;pid=S1012-29662021000200225&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_pdf&amp;pid=S1012-29662021000200225&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: Candida es uno de los microorganismos mayormente aislado de los hemocultivos positivos, mostrando un aumento de su prevalencia a nivel mundial debido a múltiples factores de riesgo siendo unos de los más importantes el uso de antibioticoterapia de espectro ampliado, como las quinolonas usados en pacientes críticos hospitalizados en salas de cuidado intensivo, de los cuales la literatura es tangencial en su relación con el desarrollo de candidiasis invasiva.  Materiales y metodos:  se realizó una búsqueda exhaustiva en las bases de datos biomédicas MEDLINE, PubMed, ScienceDirect, Scopus, Embase, utilizando la estrategia de búsqueda: &#8220;Candidemia AND Quinolones AND Adult&#8221; sin embargo también se usaron otras estrategias para aumentar la sensibilidad como: &#8220;Invasive candidiasis AND Quinolones&#8221; y &#8220;Candidemia OR Invasive candidiasis AND risk factors&#8221; incluyendo los idiomas inglés, español, francés y portugués, se tuvieron en cuenta artículos tipo: [Randomized Controlled Trial], [Clinical Trial], [Controlled Clinical Trial] y [Review]  Resultados:  la literatura biomédica es escasa en cuanto a la descripción de la relación entre el uso de quinolinas como factor de riesgo para desarrollar candidiasis invasiva, sin embargo se encontraron ocho estudios con significancia estadística importante que muestran una relación estrecha entre el fenómeno propuesto.  Conclusiónes:  Las quinolonas de uso sistémico como Ciprofloxacino, son un factor de riesgo confirmado asociado a infecciones invasivas por hongos tipo Candida.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Candida is one of the microorganisms most frequently isolated from positive blood cultures, showing an increase in its prevalence worldwide due to multiple risk factors, one of the most important being the use of extended-spectrum antibiotic therapy, such as quinolones used in critical patients in intensive care wards, of which the literature is tangential in its relationship with the development of invasive candidiasis,  Methods:  a search of biomedical databases MEDLINE, PubMed, ScienceDirect, Scopus, Embase, was performed using the search strategy: "Candidemia AND Quinolones AND Adult" other strategies were also used to increase sensitivity such as: "Invasive candidiasis AND Quinolones" and "Candidemia OR Invasive candidiasis AND risk factors" including English, Spanish, French and Portuguese languages, articles type were taken into account: [Randomized Controlled Trial], [Clinical Trial], [Controlled Clinical Trial] and [Review].  Results:  The biomedical literature is scarce regarding the description of the relationship between the use of quinolones as a risk factor for developing invasive candidiasis; however, eight studies were found with important statistical significance that show a close relationship between the proposed phenomenon.  Conclusion:  Systemic quinolones such as Ciprofloxacin are a confirmed risk factor associated with invasive fungal infections such as Candida.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[candidiasis invasiva]]></kwd>
<kwd lng="es"><![CDATA[quinolonas]]></kwd>
<kwd lng="es"><![CDATA[cuidados intensivos]]></kwd>
<kwd lng="es"><![CDATA[adultos]]></kwd>
<kwd lng="es"><![CDATA[factores de riesgo]]></kwd>
<kwd lng="es"><![CDATA[resistencia a medicamentos]]></kwd>
<kwd lng="en"><![CDATA[Invasive candidiasis]]></kwd>
<kwd lng="en"><![CDATA[Quinolones]]></kwd>
<kwd lng="en"><![CDATA[Intensive Care]]></kwd>
<kwd lng="en"><![CDATA[Adults]]></kwd>
<kwd lng="en"><![CDATA[Risk Factors]]></kwd>
<kwd lng="en"><![CDATA[Drug Resistance]]></kwd>
</kwd-group>
</article-meta>
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