<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0250-5460</journal-id>
<journal-title><![CDATA[Revista Boliviana de Química]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Bol. Quim]]></abbrev-journal-title>
<issn>0250-5460</issn>
<publisher>
<publisher-name><![CDATA[Universidad Mayor de San Andrés]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0250-54602022000300031</article-id>
<article-id pub-id-type="doi">10.34098/2078-3949.38.3.3</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Antioxidant capacity assessment by abts of 9'Z-bixin, 9'Z-norbixin, 9'Z-methylbixin and all e-methylbixin from bixa orellana seeds]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González-Araúz]]></surname>
<given-names><![CDATA[Alexander P.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Torres-Mendoza]]></surname>
<given-names><![CDATA[Daniel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A5"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ríos-Carrera]]></surname>
<given-names><![CDATA[Nivia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Durant-Archibold]]></surname>
<given-names><![CDATA[Armando A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Solano]]></surname>
<given-names><![CDATA[Godofredo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tamayo-Castillo]]></surname>
<given-names><![CDATA[Giselle]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Molinar-Toribio]]></surname>
<given-names><![CDATA[Eunice]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Murillo]]></surname>
<given-names><![CDATA[Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,aff1  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,aff2  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af3">
<institution><![CDATA[,aff3  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af4">
<institution><![CDATA[,aff4  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af5">
<institution><![CDATA[,aff5  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af6">
<institution><![CDATA[,aff6  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af7">
<institution><![CDATA[,aff7  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af8">
<institution><![CDATA[,aff8  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af9">
<institution><![CDATA[,aff9  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2022</year>
</pub-date>
<volume>39</volume>
<numero>3</numero>
<fpage>31</fpage>
<lpage>38</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_arttext&amp;pid=S0250-54602022000300031&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_abstract&amp;pid=S0250-54602022000300031&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.bo/scielo.php?script=sci_pdf&amp;pid=S0250-54602022000300031&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The 9´Z-bixin is the major pigment present in the annatto (Bixa orellana L.) seeds. Other carotenoids present in the seeds of annatto are 9´Z-norbixin and 9´Z-methylbixin. Annatto seeds extract is used as a food colorant. In this study, we extracted and isolated 9´Z-bixin from annatto seeds. 9&#8217;Z-norbixin was obtained and purified by saponification of annatto seeds extract. Then, 9&#8217;Z-methylbixin was obtained by Steglich esterification of 9´Z-bixin with EDC/DMAP. Also, all E-methylbixin was obtained by esterification of 9&#8217;Z-bixin in acid conditions with hydrochloric acid in methanol. The antioxidant capacity of 9´Z-bixin and bixin derivatives was measured in ABTS assay to determine their structure-activity relationship. We observed that the esterification of 9´Z-bixin decreases its antioxidant capacity and that the presence of the free carboxyl group is important in the antioxidant capacity of bixin derivatives.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La 9´Z-bixina es el principal pigmento presente en las semillas de achiote (Bixa orellana L.). Otros carotenoides presentes en las semillas de achiote son la 9´Z-norbixina y la 9´Z-metilbixina. El extracto de semillas de achiote se utiliza como colorante alimentario. En este estudio, se extrajo y se aisló 9´Z-bixina de semillas de achiote. Se obtuvo y se purificó 9'Z-norbixina a partir de la saponificación de extracto de semillas de achiote. Luego, se obtuvo 9'Z-metilbixina por esterificación de Steglich con EDC/DMAP. También se obtuvo E-metilbixina por esterificación en medio ácido. La capacidad antioxidante de 9´Z-bixina y de los derivados de bixina se midió con el ensayo ABTS para determinar su relación estructura-actividad. Observamos que la esterificación de la 9´Z-bixina disminuye su capacidad antioxidante y que la presencia del grupo carboxilo libre es importante en la capacidad antioxidante de los derivados de bixina.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[9&#8217;Z-Bixin]]></kwd>
<kwd lng="en"><![CDATA[9´Z-Norbixin]]></kwd>
<kwd lng="en"><![CDATA[9´Z-Methylbixin]]></kwd>
<kwd lng="en"><![CDATA[All E-methylbixin]]></kwd>
<kwd lng="en"><![CDATA[Food colorant]]></kwd>
<kwd lng="en"><![CDATA[Antioxidant activity]]></kwd>
<kwd lng="en"><![CDATA[structure-activity relationship]]></kwd>
<kwd lng="es"><![CDATA[9&#8217;Z-Bixina]]></kwd>
<kwd lng="es"><![CDATA[9´Z-Norbixina]]></kwd>
<kwd lng="es"><![CDATA[9´Z-Methylbixina]]></kwd>
<kwd lng="es"><![CDATA[All E-methylbixina]]></kwd>
<kwd lng="es"><![CDATA[Colorante alimentario]]></kwd>
<kwd lng="es"><![CDATA[Actividad antioxidante]]></kwd>
<kwd lng="es"><![CDATA[Relación estructura-actividad]]></kwd>
</kwd-group>
</article-meta>
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