Resumen

EGUIGUREN, Loretto Charmaine Mata  y  CLAVIJO, Christian Gabriel Villa. Diagnostic and clinical treatment of seronegative antiphospholipid syndrome. Vive Rev. Salud [online]. 2023, vol.6, n.16, pp.240-250.  Epub 14-Feb-2023. ISSN 2664-3243.  https://doi.org/10.33996/revistavive.v6i16.222.

Antiphospholipid syndrome (APS) was first described in 1982 by the scientist Graham R. V Hughes. In 2003 Hughes and Khamasht managed to identify an uncommon variable of FAS called seronegative, which manifests with the characteristic thrombolytic picture of this disease however there is absence of positivity in serological tests, because it is a pathology of difficult identification and diagnosis requires special attention since it can lead to multiple complications if not treated in a timely manner. Objective. To describe the diagnosis and treatment of Seronegative Antiphospholipid Syndrome. Methodology. A systematic review was carried out including original studies, meta-analysis and experimental studies published in the last 5 years in English and Spanish. Virtual databases such as Pubmed, Scielo and Google Scholar were used. Conclusion. Seronegative antiphospholipid syndrome is a pathology that is difficult to recognize due to the negativity reflected in serological tests. For diagnosis, the clinical manifestations of the patient should be taken into account initially to obtain a suspicion, after which it is important to carry out serological tests in which the detection of antibodies that are part of the criteria for FAS should be performed first.

Palabras clave : Antiphospholipid Síndrome; Diagnosis; Therapeutics.

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