Abstract

PINGUIL YUGSI, Mercy Elizabeth; ESTEVEZ MONTALVO, Edmundo; ANDRADE CAMPOVERDE, Diego  and  ALVARADO, María Fernanda. BLEE-producing Escherichia coli of community and hospital-acquired origin. Vive Rev. Salud [online]. 2022, vol.5, n.14, pp.518-528.  Epub Aug 04, 2022. ISSN 2664-3243.  https://doi.org/10.33996/revistavive.v5i14.165.

Escherichia coli (E. coli) is one of the main pathogenic enterobacteria causing infections associated with health care, with high impact at hospital and community level due to its high morbidity and mortality rate. The defense mechanism of these bacteria is through the generation of resistance enzymes, such as the production of extended spectrum beta-lactamases. Objective. To characterize extended-spectrum beta-lactam resistance based on its prevalence in Escherichia coli isolates of community and intrahospital origin in the city of Azogues. Materials and methods. Descriptive, documentary study. The population consisted of 877 records from the WHONET database of E. coli isolates from community and in-hospital samples from the Homero Castanier Crespo Hospital laboratory. Results. 75.5% of the isolates were from females and 24.5% from males. The mean age was 43.5 years. The frequency of BLEE-producing E. coli was 17.7%, with a higher frequency in males (23.7%), in the clinical area (25.2%), surgery (16.8%) and in surgical wound samples (11.6%). Resistance to beta-lactams predominated (84.5%) and first and second generation cephalosporins was greater than 48%. Carbapenems (imipenem 97.3% and meropenem 96.7%), aminoglycosides (amikacin 94.9 and gentamicin 80.5), fosfomycin (90.3) and nitrofurantoin (96.7%) showed higher sensitivity. Conclusions. The constant monitoring of BLEE enzymes allows the early detection of sensitivity patterns and at the same time guides to an adequate therapeutic treatment, avoiding the generation of new resistances and high morbidity and mortality rates.

Keywords : Escherichia coli; Microbial resistance to antibiotics; beta-lactamases; Infection.

        · abstract in Spanish | Portuguese     · text in Spanish     · Spanish ( pdf )