Resumo

IDROVO CONDO, Daniel Fernando. Mechanisms of bacterial resistance against ceftazidime avibactam. Systematic Review. Vive Rev. Salud [online]. 2022, vol.5, n.13, pp.257-272.  Epub 27-Maio-2022. ISSN 2664-3243.  https://doi.org/10.33996/revistavive.v5i13.1146.

Antibiotic resistance represents a worldwide problem determined by the ability of batteries to develop resistance mechanisms that allow them to adapt and survive in the environment in which they operate. Since its approval in 2015 by the Food and Drug Administration (FDA), the ceftazidime-avibactam (CAZ/AVI) combination has proven to be very efficient against Gram-negative bacilli that produce carbapenemase, but like other strategies against multiresistant bacteria, it is not exempt from the development of resistance mechanisms. Methods. a systematic review of the literature was carried out in the Web of Science, PubMed and Scopus databases following the PRISMA methodology, including 29 articles in which resistance to CAZ/AVI was reported in clinical isolates. Results. The most relevant resistance mechanisms were mutations in the blaKPC gene at position 179 (D179Y) in the conserved omega loop, stimulated by previous exposure to CAZ/AVI, thus generating new variants such as blaKPC-31 and blaKPC-33. Conclusions. The evident presence of resistance mechanisms to CAZ/AVI, despite being a combination of relatively recent use, calls for the appropriate use of this combination.

Palavras-chave : Ceftazidime-avibactam; KPC mutation; Bacterial resistance to antibiotics; resistance to ceftazidime-avibactam; Carbapanem-resistant Enterobacteriaceae.

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