Resumo

FUENMAYOR-GONZALEZ, Luis; FAJARDO-LOAIZA, Thalía; RIVADENEIRA-DUENAS, Josué  e  AREVALO-MANCHENO, Juan. Microbiota, probiotics, and the human behavior. Vive Rev. Salud [online]. 2022, vol.5, n.13, pp.75-86.  Epub 19-Fev-2022. ISSN 2664-3243.  https://doi.org/10.33996/revistavive.v5i13.1132.

Nowadays, the relationship that the intestinal microbiota maintains with various organs and systems of the human body has gained more importance. Especially relevant are the relationships of the microbiota with the Central Nervous System, behavior, and the development and treatment of various diseases. The relationship between the intestinal microbiota and the brain is a product of neuroendocrine and neuroimmune stimuli that can act bilaterally, even generating changes in human behavior. Moreover, clinical and paraclinical studies have demonstrated the association between the microbiota-gut-brain axis and neurological disorders such as Parkinson's disease or depressive disorder. The objective of this article is to carry out an analysis of the studies concerning the function of the microbiota-gut-brain (MGB) axis, as well as to identify new evidence about the use of probiotics in the adjunctive treatment of several neuropsychiatric disorders. A systematic search of the bibliography was carried out using keywords and MeSH terms and presented in a discussion format according to the subtopics: microbiota-gut-brain axis, mechanisms of action, microbiota, and its relationship with behavior and regulation on probiotics. The conclusion was that the evidence demonstrates the relationship between the microbiota-gut-brain axis and several neuropsychiatric disorders in humans. In addition, the administration of probiotics can modify the MGB axis and constitute an alternative for adjuvant therapy in these behavioral disorders.

Palavras-chave : Gastrointestinal Microbiome, Probiotics; Behavior; Cerebrum, Microbiota.

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