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Vive Revista de Salud
Print version ISSN 2664-3243
Abstract
MENDIETA ASTUDILLO, Veronica; GALLEGOS MERCHAN, Juan Diego and PENA CORDERO, Susana Janeth. Frequency of (ESBL) (AmpC) and CARBAPENEMASES in urine culture samples, in Escherichia Coli strains of community origin. Vive Rev. Salud [online]. 2021, vol.4, n.11, pp.275-284. ISSN 2664-3243. https://doi.org/10.33996/revistavive.v4i11.101.
Escherichia coli (E. coli) is part of the group of the main Enterobacteriaceae, which due to its high prevalence and capacity to generate resistance to certain antimicrobials is the cause of several infectious processes of community origin, especially urinary tract infections. The defense mechanism of these bacteria is enzymatic activation through ESBL-type Betalactams, AmpC and CARBAPENEMASES.
Materials and Methods.
Cross-sectional documentary design, with a quantitative approach, the population consisted of 671 uroculture reports processed in the period January - April 2020 at the Neolab Clinical Laboratory in the city of Cuenca in Ecuador.
Results.
96.4% of the samples are from female patients and 3.6% from male gender, the average age, the study had a higher prevalence in 40-year-old patients. 7.62% of the samples were positive ESBL, 0.13% AmpC and 0% CARBAPENEMASES. The antibiotics with the highest effectiveness rate for treating ESBL-producing E.coli in urine cultures were Nitrofurantoin, Gentamicin, and Fosfomycin, with effectiveness rates of 87.93%, 79.31%, and 70.68%, respectively. However, antimicrobials such as Ampicillin showed a resistance of 100% and Trimethoprim sulfamethoxazole of 72.41%.
Conclusion.
The frequency detection of ESBL, AmpC and Carbapenemases enzymes guides an adequate therapeutic treatment. Patients with ESBL-producing bacteria have a high mortality rate when treated with antimicrobials that the bacteria have high resistance.
Keywords : Urinary Infections; Bacterial Drug Resistance; Microbial Sensitivity Testing; Community Acquired Infections; Enzymes.
