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Vive Revista de Salud
Print version ISSN 2664-3243
Abstract
TENESACA SERPA, Andrea and ANDRADE CAMPOVERDE, Diego. Genes involved in the severity of SARS-cov- 2 infection. Vive Rev. Salud [online]. 2021, vol.4, n.11, pp.193-206. ISSN 2664-3243. https://doi.org/10.33996/revistavive.v4i11.95.
COVID-19 is a pathology caused by SARS-CoV-2, a zoonotic virus capable of producing multi-organ pathologies. The symptomatology it produces is varied. Some patients present severe conditions after infection. Studies have shown that the genetic role has a great influence on the response to infection.
Methodology
. A systematic review was carried out, based on the search and analysis of original articles in high impact databases such as PudMed, Google Scholar, Scopus, Taylor & Francis, ProQuest SciencieDirect; Boolean operators, inclusion and exclusion criteria were used in order to obtain accurate information. Immunity genes such as HLA, ACE2 and TMPRSS2 are directly involved with the severity of SARS-CoV- 2 infection. Polymorphisms of androgen receptor polyQ genes, ABO factor contribute to a deterioration of the pathological state as a consequence of COVID-19.
Conclusion
. The studies demonstrated that there are genes involved in the severity of SARS-CoV-2 infection, since they mention that polymorphisms of the HLA, androgen receptor polyQ and ABO factor genes produce susceptibility to COVID-19. Likewise, ACE2 and TMPRSS2 genes intervene in the entry and expansion of the virus. In the different breeds there are variants of the CCL2 and MBL genes, which indicates that some populations are more susceptible than others.
Keywords : COVID-19; SARS-CoV- 2; HLA; TMPRSS2; CCL2; MBL; IL6; polymorphism; polyglutamine; pathogenesis; immunity, susceptibility, ABO factor.
