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Vive Revista de Salud
versão impressa ISSN 2664-3243
Resumo
VALVERDE PULLA, Jessica e PRIETO FUENTEMAYOR, Carem. HOMA-IR Index as indicator of the risk of Endocrine-Metabolic diseases in obese children and adolescents. Vive Rev. Salud [online]. 2021, vol.4, n.11, pp.60-79. ISSN 2664-3243. https://doi.org/10.33996/revistavive.v4i11.86.
Childhood obesity contributes to the presence of Insulin Resistance (IR), which in turn increases the risk of endocrine-metabolic disorders in childhood. The HOMA-IR has proven to be very useful for the detection and monitoring of these pathologies, however, the physiological and pathological variables to which its calculation is subject must be considered. It also has a good correlation with the euglycemic clamp for the detection of IR, but it is essential to mark specific cut-off points to diagnose and identify pediatric patients at high risk of Metabolic Syndrome and Diabetes 2, which would avoid complications in adulthood.
Objective.
It is to evaluate the HOMA-IR, as an indicator of risk of endocrine-metabolic diseases in the pediatric population with obesity; as well as showing its limitations and diagnostic utility.
Method.
A systematic review was carried out in the bases: Science Direct, Scopus, Scielo and Pubmed; using the descriptors: "HOMA-IR Index", "Childhood Obesity" and "Insulin Resistance". The search was restricted to complete articles in Spanish, English and Portuguese, between 2007 and 2020. 3855 articles were identified, after applying the analysis phases, 10 articles were selected for the review, each with specific cut-off points for the population. studied and its respective ROC curve.
Conclution.
It was concluded that the HOMA-IR is a reliable model for the diagnosis of early IR in children, which allows a preventive and diagnostic therapeutic intervention, it is an excellent predictor of endocrine-metabolic diseases and future cardiovascular complications.
Palavras-chave : HOMA-IR; insulin resistance; pediatric obesity; endocrine-metabolic diseases.
