Abstract

GONZALES-LLONTOP, Luis; CHOTON-CALVO, Mariel  and  CHICO-RUIZ, Julio. Cytoprotective effect of Aloe vera L. "aloe" in rats with gastric damage caused by indomethacin. Rev. Inv. Cs. Agro. y Vet. [online]. 2021, vol.5, n.14, pp.262-273.  Epub Aug 31, 2021. ISSN 2664-0902.  https://doi.org/10.33996/revistaalfa.v5i14.116.

The cytoprotective effect of Aloe vera L. "aloe" was evaluated in rats with gastric damage caused by indomethacin. 50 rats, 4 months old and 250 g of average weight, were used. The animals were distributed in a group of ten for each of the treatments. Group 1 (control) received SSF (0.9%), group 2 (control) received indomethacin (20 mg / kg), and problem groups (3, 4, and 5) received one, two, and three doses of aloe (50 mg / kg), respectively. The first dose was administered 4 hours before indomethacin and the other doses in 4-hour successions. After one hour they were anesthetized and euthanized. In the levels of macroscopic and microscopic gastric lesions, significant differences were found between the control group (p <0.001) and the problem groups. In the groups treated with A. vera L. (p> 0.05), no significant differences were found. In our experimental conditions the application of an extract of aloe in rats with gastric damage showed histoprotective effect.

Keywords : Aloe vera L.; indomethacin; ulcers; rats; natural medicine.

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