Introduction.

According to the National Health Information System (SNIS), until 2022 in Bolivia, gastric diseases occupied third place among the non-communicable diseases with the highest frequency of care at the first and second levels, an index that has continued to increase in the last two years. This promotes the development of natural treatments that produce fewer side effects than conventional treatments. Among the alternatives, the use of plants and foods that help protect the stomach stands out. In this sense, the beneficial effect of chewing coca in the treatment of ulcers, lesions, spasms and pain, as well as nausea and diarrhea, has been reported in traditional medicine and in some scientific publications. On the other hand, it has been reported in scientific publications that the consumption of unripe (green) banana offers a protective effect on the gastric mucosa, which strengthens resistance to lesions and promotes the healing of ulcers.

Objective.

The objective of this research is to evaluate the gastroprotective effect of hydroethanolic extracts of Musa paradisiaca (banana), Erithroxylum coca (coca) and a combination of both, in an in vivo pharmacological model.

Materials and methods.

Hydroethanolic extracts of both plant species (green banana and coca leaves) were obtained, which were tested in the ethanol-induced gastric ulcer model. This allowed the evaluation of the gastroprotective activity of the extracts at a dose of 500 mg/kg and their combination at a dose of 1500 mg/kg, through macroscopic analysis of ulcers, their score and the determination of the total area of the lesion (mm2) and the relative area of the lesion (%).

Results.

The results obtained showed that the banana extracts and the combination of banana and coca extracts present a significant gastroprotective activity against the aggressive agent ethanol.

Conclusion.

Hydroethanolic extract of banana and combination with hydroethanolic extract of coca have showed gastroprotective activity in vivo model.

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