Resumo

BALLON PAUCARA, Wendy Guadalupe et al. Effect of a natural Product based on Amaranth, Quinoa and Tarwi on Lipid Profile in patients with Obesity and type 2 Diabetes Mellitus. Rev.Cs.Farm. y Bioq [online]. 2021, vol.9, n.1, pp.28-45. ISSN 2310-0265.

ABSTRACT Introduction: Obesity is a chronic disease that leads to the onset of cardiovascular diseases and type 2 diabetes mellitus (T2DM). Overweight, obese or T2DM patients generally have a lipid profile with high blood levels of cholesterol, triglycerides, LDL and VLDL-c and low levels of HDL-c. Pseudocereals such as Amaranthus caudatus (Amaranth), Chenopodium quinoa (Quinoa) and Lupinus mutabilis (Tarwi) present in the Andean region of Bolivia, have potentially nutraceutical properties, with a high content of macronutrients and various phytochemicals with biological activity such as quinolizidine alkaloids, saponins, triterpenes and γ-conglutin. Objective: To determine the effect due to natural product intake made with Amaranth, Quinoa and Tarwi on the lipid profile in patients with obesity and T2DM. Method: Controlled, prospective, double blinded and crossed Preliminary Clinical Assay, performed in the Pharmacology Area of Instituto de Investigaciones Fármaco Bioquímicas from Facultad de Ciencias Farmacéuticas y Bioquímicas, Universidad Mayor de San Andrés. Results: The intake of a product made from Amaranth, Quinoa and Tarwi (AQT) flour for 3 months, promoted a significant decrease in cholesterol, triglycerides, LDL and VLDL-c in overweight diabetic patients (DM2) (BMI> 25) However, HDL-c levels did not undergo significant changes. Conclusion: Therefore, the AQT product has beneficial effects on the lipid profile in patients who are overweight or obese and at risk of cardiovascular disease and T2DM.

Palavras-chave : Nutraceutical; Lipid profile; Obesity and T2DM.

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