Resumo

CAVERO OLGUIN, Victor Hugo. Chlorine Dioxide, Miricles Do Not Exist. Rev.Cs.Farm. y Bioq [online]. 2020, vol.8, n.1, pp.79-98. ISSN 2310-0265.

Abstract Objectives: To contribute with a bibliographic review about the action of chlorine dioxide on certain microorganisms and bio-molecules. To review its uses, toxicity, chemical and biochemical reactivity besides studies carried out in animal models. To understand what the extent of the studies in animal models is and relate them with the possibility of carrying out studies in humans. Methodology: An exhaustive review has been done about chlorine dioxide. Its use as an antiseptic, toxicity, molecular structure, molecular oxygen generation, reactivity with biomolecules and experiments on animal models to understand at which state of the art the research on this molecule is. Every search was carried out in data bases of scientific papers as well as by information exchange with professionals of the field and certain curiosities of the popular collective. Results: The structure and molecular reactivity of chlorine dioxide determines a high reactivity with certain aminoacids and proteins, therefore explaining its inhibitory biological activity. Several studies demonstrated this inhibitory activity against different microorganisms, including viruses. These data and a clinical assay in humans determined a low toxicity at low concentrations. Nonetheless, the lack of more human clinical studies in controlled situations prevents it from the possibility to extrapolate those data to human beings in order to mitigate infectious diseases like Covid-19. Conclusions: The reactivity of chlorine dioxide remains clarified and its action on proteins explains the effective action against microorganisms like viruses. Its low toxicity in studies carried out in animal models opens the possibility of more clinical studies. Extrapolate data obtained so far to human beings is not correct.

Palavras-chave : Chlorine dioxide; Covid-19; SARS-CoV-2.

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