Abstract

HERNANDEZ, Anahí et al. Pharmaceutical quality of tablets of metronidazole and capsules of amoxicilin available in the honduran market  . Rev.Cs.Farm. y Bioq [online]. 2020, vol.8, n.1, pp.33-52. ISSN 2310-0265.

Abstract Introduction: Metronidazole, an antiparasitic and antimicrobial, and amoxicillin, a broad-spectrum aminopenicillin, are widely used drugs. Aims: to determine the pharmaceutical quality of oral administration formulations available in the Honduran market, in the city of Tegucigalpa. Methods: Products from five brand of metronidazole tablets (500 mg) and amoxicillin capsules (500 mg) were analyzed, respectively, all of them within their period of validity of use. For this, the technological, chemical and chemical properties of the tablets and capsules were evaluated, such as average weight, hardness, evaluation of active principle, uniformity of content, dissolution test, dis-solution profile, area under curve and dissolution efficiency. Results: Not all medicinal specialties contained information on storage conditions, regarding temperature, light and humidity, stated on the labels and leaflets. According to the technological and chemical evaluation, all the evaluated products satisfied the specifications of the pharmacopeia. However, there are statistically significant differences between the products according to in vitro dissolution tests. The release of metronidazole was adjusted to the Hixson-Crowell model, while that of amoxicillin, in two formulations was adjusted to the Higuchi model, and in the rest to the Hixson-Crowell model. Conclusions: The need for greater surveillance of the drugs that are marketed in the country is suggested, in order to verify compliance with quality standards.

Keywords : pharmaceutical quality; metronidazole; multisource; in vitro dissolution.

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