Abstract

CALLAPA, JORGIA et al. Epidemiological, serological and molecular study of the chagas disease in the bolivian amazon. Rev.Cs.Farm. y Bioq [online]. 2018, vol.6, n.2, pp.63-78. ISSN 2310-0265.

Abstract The present study is part of the project PIA-ACC.UMSA.01 "Search for New Endemic Areas of Chagas Disease in the Bolivian Amazon as an effect of Climate Change", which has allowed us to carry out the epidemiological - serological and molecular study of Cha-gas disease in asymptomatic people living in six regions of the Bolivian Amazon: Riberalta; Guayaramerín; Cobija; Trinidad; San Joaquín and San Borja, who in their majority belonged to the diverse indigenous towns, affected by the poverty. Clinical exploration and serological and molecular diagnostic tests of Chagas diseasewere performed on the population of each region atno cost.The participation of the people was coordinated with the Central de Pueblos Indígenas del Beni (Central de Pueblos Indígenas del Beni) and by signing the in-formed consentall the volunteer participants were submitted to the study. A total of 338 samples were processed with the ELISA serological tests; HAI and IFI and the molecular test of the PCR at the end point. The se-ropositivity was 6.2% (21 cases) and the PCR was positive in 3.8% (13 cases). Of the total positive Chagas cases, 42% were cases of migrants from endemic regions such as Cochabamba, Santa Cruz, Chuquisaca and Yungas de La Paz. Likewise, the main risk factors associated with the disease were identified, noting among other aspects that inhabitants of these regions have little knowledge about Chagas disease; however, they are aware of the appearance of strange diseases in these regions due to the climatic variations detected in recent years and evidence their concern about the negative effects of climate change

Keywords : Chagas Disease; Bolivian Amazon; Diagnosis; Epidemiology.

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