Abstract

GUTIERREZ DURAN, MARÍA DEL PILAR  and  GONZALES DAVALOS, EDUARDO. Evaluation of the anti-inflammatory and analgesic effect of the association of extracts of Xanthium spinosum L. and Urtica urens L. in the murine model. Rev.Cs.Farm. y Bioq [online]. 2018, vol.6, n.2, pp.15-26. ISSN 2310-0265.

Abstract The high incidence of adverse effects caused by the chronic use of anti-inflammatory drugs has led to the search for alternative therapies or coadjuvants based on the use of medicinal plants. In Bolivia, the plant species Xanthium spinosum L. and Urtica urens L. are traditionally used in inflammatory processes. In this work the antiinflammatory and analgesic effect of different types of extracts is investigated: aqueous, ethanolic, dichloromethane, ethereal extract of the plant species Xanthium spinosum L. and Urtica urens L. and the association of aqueous and ethanolic extracts of the same plant species, in murine models. The highest effects of inhibition of inflammation at a dose of 1.5 g/kg of body weightwere recorded seven hours after the inflammatory process for the aqueous (64.8%) and ethanolic (68.7%) extracts of X. spinosum L .; the percentage of inhibition for the aqueous and ethanolic extract of U. urens L. was 57% and 51.5% respectively. The inhibition of algesia was observed in the dichloromethane and ethanolic extracts of both species, reaching a maximum of 72.8% inhibition with the etha-nolic extract of U. urens L. The evaluation of the association of aqueous extracts of both species, at a dose of 0.75 g/kg of body weight of each extract, showed an anti-inflammatory effect with a percentage of inhibition of inflammation of 68.95% and a percentage of inhibition of algesia of 54.8%; whereas the association of the ethanolic extracts of these species showed only anti-inflammatory effect.

Keywords : Xanthium spinosum L.; Urtica urens L. antiinflammatory activity.

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