Abstract

PALMA TOVAR, CAMILA ISABEL  and  VASQUEZ MICHEL, ANETH MARÍA. Incidence of Mycobacterium Tuberculosis in Extrapulmonary Specimens Processed by the MODS - TB Assay Seladis Institute from June 2015 to December 2016. Rev.Cs.Farm. y Bioq [online]. 2017, vol.5, n.1, pp.99-110. ISSN 2310-0265.

Abstract Extrapulmonary tuberculosis manifests tuberculosis that happens when the bacteria Mycobacterium tuberculosis crosses the pulmonary parenchyma to other organs through hematogenous, lymphatic vias or by contiguity. Among diverse detection methods of the Koch bacillus in different place's trough pulmonary parenchyma, the Microscopic Observation Drug Susceptibility Assay (MODS TB) consists in a liquid medium selective culture for M. tuberculosis that allows finding susceptibility profiles for Isoniazid and Rifampicin. In thisstudy we appealed to the Molecular Microbiology laboratory reports of SELADIS Institute, from June 2015 to December 2016. Found out the following results: the incidence of extrapulmonary tuberculosis is of 17,16% in samples of extrapulmonary origin; cerebrospinal fluid (LCR), ascetic liquid and pleural liquid are the kinds of extrapulmonary samples with the high-est incidence of Mycobacterium tuberculosis (with 65%, 21,74% and 8,7% of positive results respectively); male patients, adults (from 27 to 59 years-old) and citizens from La Paz City showed a higher occurrence of extrapulmonary tuberculosis. The results of this study allow having an overview of extrapulmonary tuberculosis in La Paz. Counting with the MODS TB tool, wich sensitivity and specificity has been reported in other jobs and has been standardized at the Molecular Microbiology laboratory of SELADIS Institute, where this this research accomplished. The provided information will allow to increase the cientific - epidemiological knowledge that we have about extrapulmonary tuberculosis and encourage the research in this field.

Keywords : Extrapulmonary tuberculosis; pathogeny of extrapulmonary tuberculosis; epidemiology of extrapulmonary tuberculosis; MODSTB.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )