Resumen

CUTIPA, WENDY JACQUELINE et al. Association of Angiotensin Converting Enzyme Genetic Polymorphisms with Systemic Lupus Erythematosus in Bolivian Lupus Patients. Rev.Cs.Farm. y Bioq [online]. 2017, vol.5, n.1, pp.57-66. ISSN 2310-0265.

Abstract Systemic Lupus Erythematosus (SLE) a systemic autoimmune disease, affects different organs, being kidneys the most frequently affected. Many studies in different population groups have reported associations between the intron 16 of the gene encoding angiotensin converting enzyme (ACE) polymorphism and SLE susceptibility and its clinical manifestations, in particular lupus nephritis. Associate genotypic and allelic insertion/deletion (I/D) of the ACE gene polymorphism in SLE patient's susceptibility and the clinical manifestations were the aims of the present study. 87 lupus patients who met at least four clinical criteria of the American Society of Rheumatology and 85 healthy controlswhere included. All participants gave their informed consent to participate in the study. Allelic and genotypic ACE I/I, I/D and D/D polymorphisms were detected by polymerase chain reaction (PCR). In patients with SLE, the genotypic frequency of I/I, I/D and D/D were 47.1, 48.3 and 4.6%; and 68.2,31.8 and 0% in control group respectively. Allele frequency in SLE represent: Insertion 71.3%, Deletion 28.7% and Insertion 84.1%, Deletion 15.9% in control group. Allele and genotypic variants I/I and I/D of the insertion allele were associated systematically with risk to dermatological, musculoskeletal and hematologic complications. Regarding lupus nephritis allele insertion isa protectivefactor. ACE gene polymorphism here studied has not been associated to risk or protection with cardiopulmonary or neurological clinical manifestations.

Palabras clave : Systemic lupus erythematosus; angiotensin converting enzyme; lupus nephritis; polymorphism.

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