Abstract

TABORGA MANRIQUE, Ximena et al.   Presence of micronuclei in exfoliated cells of the oral mucosa in people exposed to genotoxic agents  . Rev.Cs.Farm. y Bioq [online]. 2016, vol.4, n.2, pp.35-44. ISSN 2310-0265.

Abstract Micronuclei are used like biomarkers in order to determinate damage in the ADN. This damage is caused by genotoxic agents and they can be the origin of mutations or cancer. In order to determinate genotoxic risk due to work and harmful habits (tobacco and alcohol), 60 samples were analyzed. Cells of the oral mucosa were collected, dyed and their micronuclei were counted using a mi-croscope. People who participated as volun-teers in this study are men and women cov-ered in a range from 21 to 68 years, who work in tanneries, laboratories, oncology, radiology, in printing houses or who have harmful habits. In all groups micronuclei were found, howev-er, people who have unhealthy habits and are exposed to some other risk factors were those who had higher number of affected cells. On the other hand, a higher percentage of micronuclei in women and elder people was found. Therefore it is concluded that all work activities mentioned and harmful habits represent a risk to the genome integrity.

Keywords : Micronucleus; genotoxicity.

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