Abstract

GUTIERREZ D., MARÍA DEL PILAR et al. Evaluation of Baccharis latifolia activity in experimental arthritis models. Rev.Cs.Farm. y Bioq [online]. 2016, vol.4, n.2, pp.21-33. ISSN 2310-0265.

Rheumatoid arthritis (RA) is a chronic autoimmune and inflammatory disease leading to pannus formation followed by the destruction of the joints; it is characterized by synovial hyperplasia, inflammation and angiogenesis. The plant species Baccharis latifolia is traditionally used in many regions of our country to treat pain, inflammation and arthritis. In the present study the antiarthritic activity of ethanol extract of B. latifolia was evaluated in murine experimental model of rheumatoid arthritis induced by adjuvant, edema estimation/thickness of the inflamed foot, hematological parameters (hemoglobin, erythrocyte sedimentation rate, erythrocyte count was assessed, total white blood cell) and radiological observation were evaluated. The oral administration of the ethanolic extract of B. latifolia (600 mg / kg p.c.) significantly inhibited (p <0,001) increased edema / paw thickness in the subchronic model of arthritis. Similarly, B. latifolia (500 mg / kg bw) significantly inhibited the increase of edema/paw thickness in the model of chronic arthritis (p <0.05, p <0.01), the weights of the animals were kept without variation during treatment. Moreover hema-tological parameters indícate that hemoglobin levels decrease in arthritic mice and that this decline is reversed after administration of the extracts of B. latifolia, this same profile is observed recovery after red blood cell count. Additionally, erythrocyte sedimentation rate (ESR) increased in arthritic mice is reversed after administration of B. latifolia. The radiological analysis showed the effect of ethanol extract of B. latifolia in delaying bone destruction. The results suggest that the ethanolic extract of B. latifolia has potential antiarthritic activity.

Keywords : Baccharis latifolia; Activity antiarthritic; Complete Freund's adjuvant.

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