Abstract

MAMANI POMA, MERY AMANDA3. Estudio de degradación de la aspirina en tabletas de diferentes marcas comercializadas en la ciudad de La Paz en la gestión 2015. Rev.Cs.Farm. y Bioq [online]. 2016, vol.4, n.1, pp.115-126. ISSN 2310-0265.

Abstract Aspirin is a drug widely used in our country as an analgesic, antiinflammatory, antipyretic and antiplatelet, therefore justifies the study of degradation of aspirin to salicylic acid causes irritation to the stomach lining, as well as its control Quality aspirin tablets to verify that it meets all specifications and will not cause any damage on the health of the patient. The study of degradation of Aspirin salicylic acid is performed by the valuation method HPLC (high performance liquid chromatography resolution) for determining the limit of free salicylic acid in tablets of 100 mg of aspirin three different brands marketed in pharmaceutical equivalence the city of La Paz in 2015. The management study is complemented by conducting checks Manufacturing Information where all drug manufacturing information is collected, such as leak test to verify the closure or sealing of the dosage form , Uniformity of Dosage Units checking their weight variation, dissolution testing to verify drug bioavailability in vitro simulated gastric filled at physiological temperature and tested for HPLC assay calculating the percentage of active ingredient per tablet by Internal Standardization standard, as limitSalicylicAcid Free mark present in each 100 mg tablet of aspirin. Acceptance criteria are given by the USP-37 2014 (United States Pharmacopeia) in order to verify compliance with security, stability and efficacy.

Keywords : Salicylic Acid; Rating; bioavailability; stability; HPLC.

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