Abstract

YANARICO, JUAN GONZALO¹ et al. Relación de los polimorfismos Na1 y Na2 del receptor FcyRiiib con lupus eritematoso sistémico en pacientes bolivianos. Rev.Cs.Farm. y Bioq [online]. 2016, vol.4, n.1, pp.85-92. ISSN 2310-0265.

Fcy Receptors for the crystallizable fragment "Fc" of immunoglobulin class G ( IgG) are the bridge between the humoral and cellular immune response, these receptors are divided into: FcyRIA, FcyRIB; FcyRIlA, FcyRIIB; FcyRIIIA, FcyRIIIB. FcyRIIIB receptor has bialilic codominant polymorphism that is expressed in neutrophils and is called Neutrophilic Antigen (NA), which has two variants NA1 and NA2. They have been identified in different studies as genetic factors that influence susceptibility to Systemic Lupus Erythematosus (SLE) or lupus nephritis (NL). There is a difference in binding capacities to the Fc portion of IgG by NA1 NA2 alleles, that may be asso-ciated with the inefficient removal of apoptotic cells and immune complexes. This study tried to establish the existence of genetic polymorfism association between NA1 and NA2 FcyRIIIB polymorphism with thesusceptibility to SLE and N L. 134 SLE patients and 150 healthy controls werestudied. All participantsgave the informed consent to participate in the study. The FcyRIIIB polymorphism was determined by PCR, using allele-specific primers. The results allowed to observe that the frequencies of the NA1/NA1, NA1/NA2 and NA2/NA2 genotypes are 0.57, 0.39 and 0.04 for the control group; and 0.20, 0.73, 0.07 respectively for SLE patients.TheSLE patients showed apredominant of genotype NA1 /NA2, being the NA2 allele a risk factor for SLE. The NA/NA1 genotype showed statistically significantassociation to NL risk (Odds ratio 2.52, p<0.001).We conclude that individuals carrying the NA1/NA2 genotype or carrying the NA2 allele are more likely to develop SLE and lupus patientwhen carrying the NA1/NA1 genotype are more likely to trigger N L.

Keywords : Systemic Lupus Erythematosus; Polymorphism; FCyRWB Receptors; Autoimmunity.

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