Abstract

RIVERA-CORONADO, Nileth Daysy  and  PEREZ-DELGADO, Orlando. In vitro antifungal activity of the diluted crude extract of the scorpion venom Hadruroides charcasus (Karsch 1879) against Candida albicans. J. Selva Andina Res. Soc. [online]. 2019, vol.10, n.2, pp.96-104. ISSN 2072-9294.

Abstract The objective was to evalúate the in vitro antifungal activity of the diluted crude extract of the scorpion venom Hadruroides charcasus (Karsch 1879) against Candida albicans. It was an experimental study, 54 experimental units were used (9 poison concentrations, 2 strains and three repetitions). The venom of the scorpion was obtained by electrical stimulation. The double serial dilution method was determined at different concentrations of 100%, 50%, 25%, 12.5%, 6.25%, 3.125%, 1.56%, 0.78%, 0.39%. To evalúate the antifungal activity, the microdilution method was used to determine the Mínimum Inhibitory Concentration (MIC). The results showed that by means of the microdilution method that for the strain n ° 1 presented a mínimum inhibitory concentration (MIC) to 25% of the diluted raw venom, very different was for the strain n ° 2 did not present CMI. It was concluded that the fmdings of the current study show that the diluted crude extract of the scorpion venom H. charcasus possesses antifungal activity on strains of C. albicans, being possible to use it as a témplate for the design and development of new antifungal drugs.

Keywords : Hadruroides charcasus; Candida albicans; antifungal; scorpion venom.

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