Abstract

LINARES TERRAZAS, Daniel Angel  and  GOMEZ WEBBER, Micaela. PATENT DUCTUS ARTERIOSUS: MOLECULAR MECHANISMS OF CLOSURE AND THEIR RELATIONSHIP WITH THE TREATMENT. Rev Cient Cienc Méd [online]. 2023, vol.26, n.1, pp.67-76.  Epub June 31, 2023. ISSN 1817-7433.

The ductus arteriosus establishes an essential connection between the proximal descending aorta and the main pulmonary artery near the origin of he left pulmonary branch, being vital during fetal life and generally closing shortly after birth in most term newborns; However, in preterm infants, persistence of the ductus arteriosus is common due to vasodilator stimuli that maintain its patency and constant blood flow, requiring treatment approaches involving prostaglandin E2 inhibition and nonsteroidal anti-inflammatory drugs, although the comparison of their efficacy with conservative methods remains unclear, especially in extremely preterm infants. The present review aims to provide an understanding of the key molecular mechanisms behind the pathophysiology of patent ductus arteriosus and its therapeutic approach.

Keywords : Patent Ductus Arteriosus; Premature Infant; Prostaglandins; Ibuprofen.

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