Abstract

YAX-BATZ, Edy  and  MAZARIEGOS, Luis Felipe. FGF-23 AND KLOTHO MARKERS IN CHRONIC KIDNEY DISEASE AND ITS CARDIOVASCULAR IMPLICATION, A SYSTEMATIC REVIEW. Rev Cient Cienc Méd [online]. 2022, vol.25, n.2, pp.168-173.  Epub Dec 31, 2022. ISSN 1817-7433.  https://doi.org/10.51581/rccm.v25i2.515.

The main cause of mortality in chronic kidney disease (CKD), in 80% of patients, is due to associated cardiovascular disease, the classic biochemical parameters of bone-mineral metabolism will not yet be able to explain the pathological progression, therefore, new markers have begun to be studied in relation to cardiovascular damage, where the marker FGF-23 and its co-receptor Klotho have been found, involved in the genesis of cardiovascular damage and bone-mineral disease associated with phosphorus, which together cause cardiovascular remodeling , which has begun to further clarify this pathophysiological dynamic. This review seeks to know the implication of the FGF-23 and Klotho markers in CKD and the associated cardiovascular risk and for this purpose, a systematic review of the literature was carried out, investigating biomedical bases such as COCHRANE, Embase, LILACS, Scielo, Pub-Med, EBSCO, Hinari, Medical Societies, as well as MeSH thesauri specific to this research.

Keywords : CKD-MBD; Fibroblast growth factor-23; Renal osteodystrophy.

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