Abstract

PULGAR ANDRADE, Aram Augusto; CARVALLO RUIZ, Daniel Ernesto  and  MARTINEZ NUNEZ, Elizabeth Natalia. MECHANISMS OF TUMOR EVASION TO THE IMMUNE RESPONSE. Rev Cient Cienc Méd [online]. 2022, vol.25, n.2, pp.157-167.  Epub Dec 31, 2022. ISSN 1817-7433.  https://doi.org/10.51581/rccm.v25i2.514.

Cancer's development is determined by the proliferative capacity of tumor cells and by presenting invasive abilities and to metastasize to distant tissues. The complex relationship of this pathology with the immune system facilitates its natural evolution; thus, this bidirectionality allows cancer cells to escape from the host's regulation, evading antitumoral immune responses, through intrinsic and extrinsic mechanisms. The aim of this manuscript is to describe exhaustively, and in the most updated way possible, said mechanisms, with the objective of generating a tangible impact and more awareness the medical-scientific community, regarding the genesis of possible new and more specific diagnostic and treatment options that diminish this lethal disease's statistics. The information used to write this article was obtained from medical digital archives, including PubMed, Google Scholar, Scielo, and Elsevier, as well as specialized books in immunology and immunopathology, and articles published in the last five years. This narrative review encourages the investigation of intercellular communication routes that may be fulfilled, in the non-too distant future, for this purpose.

Keywords : antigen-presenting cells; cytokines; immune system; T-lymphocytes; tumor.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )