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Revista Científica Ciencia Médica

Print version ISSN 1817-7433On-line version ISSN 2220-2234

Abstract

VELARDE NEGRETE, Jans et al. RELATIONSHIP OF PLASMA LEVELS OF HOMOCYSTEINE AND APOLIPOPROTEIN B-100 WITH CARDIOVASCULAR RISK. Rev Cient Cienc Méd [online]. 2022, vol.25, n.2, pp.118-124.  Epub Dec 31, 2022. ISSN 1817-7433.  https://doi.org/10.51581/rccm.v25i2.509.

Introduction:

Cardiovascular diseases are responsible for 31% of world mortality, there are parameters such as homocysteine and Apolipoprotein B-100 that could be useful in predicting risk.

Objective:

To relate the plasma levels of Homocysteine and Apolipoprotein B-100 with cardiovascular risk in patients who attend the outpatient clinic of the Univalle Hospital, during July-August 2018.

Methodology:

This study is non-experimental, observational, prospective, cross-sectional, with a quantitative positivist analysis approach, with a universe of (N=I33) that was reduced to an analysis unit of 81, who met the inclusion criteria. and exclusion with a 6.83% maximum acceptable error.

Results:

52% of the patients were women. The mean age was 49.8 (range 25 to 83), the predominant age group was the elderly. According to the BMI, the study subjects are overweight (n=3I) and obesity grade I (n=24) more frequently. The elevated plasmatic levels of Apolipoprotein B in both sexes do not show a significant difference, while in those of homocysteine the difference was 8:I. It was found that the serum levels of Apolipoprotein B-100 have a low sensitivity and specificity of 19.40% and 28.42%, while those of homocysteine were 14.29% and 27.27% respectively compared to the conventional technique.

Conclusions:

Plasma levels of homocysteine and Apolipoprotein B-I00 are not predictors of cardiovascular risk.

Keywords : Apolipoprotein B-100; Coronary heart disease; Homocysteine.

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