Abstract

MONTANO RODRIGUEZ, Yamelid Katherine. CASTLEMAN'S DISEASE MULTICENTRIC VARIANT: CASE REPORT. Rev Cient Cienc Méd [online]. 2021, vol.24, n.2, pp.167-172.  Epub Dec 31, 2021. ISSN 1817-7433.  https://doi.org/10.51581/rccm.v24i2.407.

Castleman's disease is a diagnostic challenge that must be taken into account in patients with lymphadenopathy, because it belongs to a heterogeneous group of lymphoproliferative disorders, it was described by Benjamin Castleman in 1956, it is a rare pathology, of still unknown etiopathogenesis, In which several factors intervene such as viral antigenic stimulation, HHV-8, HIV, immunodeficiencies, high levels of IL-6 that lead to an inflammatory process that produces diverse symptoms, the definitive diagnosis is made with excisional biopsy.

We present the clinical case of a 41-year-old female patient who came to the emergency department with a clinical picture of approximately I year of evolution characterized by progressive weight loss, palpable lymphadenopathy, evidence of lymphoproliferative process and splenomegaly in the tomography, HIV negative, anemia and compromise of the general state.

Keywords : Castleman's disease; Angiofollicular lymphoid hyperplasia; Lymphoid hyperplasia; Lymphoproliferative disorders; Lymphadenopathy.

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