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Revista Científica Ciencia Médica
versión impresa ISSN 1817-7433versión On-line ISSN 2220-2234
Resumen
ALEGRE ANDRADE, Patricia. EFFECT OF INTRATHECAL DEXMEDETOMIDINE AND MORPHINE AS ADJUVANTS IN OBSTETRIC ANESTHESIA. Rev Cient Cienc Méd [online]. 2020, vol.23, n.2, pp.184-191. ISSN 1817-7433.
The use of adjuvants in obstetric anesthesia, useful to decrease the dose of local anesthetics. The addition of a new drug such as spinal dexmedetomidine ranging from 5 μg to 10 μg in the world report. Objectives: To compare the effect of spinal administration of dexmedetomidine and morphine plus hiperbaric bupivacaine in patients undergoing cesarean section. Methods: Prospective double-blind clinical trial, 99 randomized patients in 3 groups:group D2 (fentanyl 10 μg , bupivacaine 9 mg and dexmedetomidine 2 μg ); group D3 (fentanyl 10 μg , bupivacaine 9 mg and dexmedetomidine 3 μg ) and group M (fentanyl 10 μg , bupivacaine 9 mg and morphine 100 μg ). Evaluation of hemodynamic parameters, duration of motor block, need for vasopressor and complications. Statistical analysis: ANOVA for quantitative variables. Chi-squared tes was used for nominal variables. P value <0.05 is significant. Results: The duration of the longer Motor Block was in the D2 group (140.3 ± 30.7 minutes), followed by the D3 group (142.4 ± 16 minutes) and the M group of 107 ± 14.6; In the dexmedetomidine groups, it has sedation and hemodynamic stability. The need for rescue was in group M; the amount of vasopressor used was 1 ± 1.7 ml in group D2; 1.8 ± 2.9 ml in group D3 and 1.7 ± 2.1 ml group M. Hypotension is the most frequent complication. Conclusions: Dexmedetomidine 2 μg better hemodynamic stability with prolonged motor block and less need for vasopressor.
Palabras clave : obstetric anesthesia; cesarean section; dexmedetomidine; morphine.