Abstract

GUTIERREZ CHOQUE, Bismar Jorge  and  ARUQUIPA QUISPE, Carla Jimena. COVID-19: VIROLOGICAL ASPECTS AND PATHOGENESIS. Rev Cient Cienc Méd [online]. 2020, vol.23, n.1, pp.77-86. ISSN 2077-3323.

The new coronavirus 2019, later known as SARS-CoV-2, has generated a new pandemic and today efforts are being made to control it, investigations are made of the genomic structure of the virus and also of pathogenic mechanisms, first describing its structure and thus its function, as well as in relation to its union with the receptors that are expressed in its most affected organs. The structural relationship found in the SARS-CoV-2 Binding Domains are compatible with the SARS-CoV binding domains. There are differences in some segments of the chain, but this does not seem to alter the lethality of the virus. The use of cryomicroscopy techniques helped to recognize viral surface structures and to describe their binding to the ECA2 receptor. In addition, in this way, targets with therapeutic potential can be set.

Keywords : Coronavirus; SARS virus; Infection.

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